CAJ | 학술논문

　　目的：观察甲状腺功能亢进症(hyperthyroidism,甲亢)患者治疗前后骨密度与骨代谢生化指标变化的特点,以供临床参考。方法：以2011年6月~2012年6月我院收治的甲亢患者74例为研究对象,均给予口服甲巯咪唑、维生素D、乳酸钙、阿仑膦酸钠等药物治疗。连续用药1年,观察治疗前后Ca、P、ALP、UCa、UP等骨生化代谢指标的变化,并测定腰椎、股骨颈、大粗隆等部位BMD的差异。结果：与治疗前相比较,治疗后患者Ca、ALP、UCa明显下降,腰椎、股骨颈、大粗隆等部位BMD明显上升,有显著的统计学差异(P<0.05)。治疗前后P、UP比较,无统计学差异(P>0.05)。结论：在抗甲亢药物治疗基础上补充维生素D、钙剂和阿仑膦酸钠,可调节甲亢患者骨代谢,延缓骨质疏松进程,具有积极的临床意义。
　　목적：관찰갑상선공능항진증(hyperthyroidism,갑항)환자치료전후골밀도여골대사생화지표변화적특점,이공림상삼고。방법：이2011년6월~2012년6월아원수치적갑항환자74례위연구대상,균급여구복갑구미서、유생소D、유산개、아륜련산납등약물치료。련속용약1년,관찰치료전후Ca、P、ALP、UCa、UP등골생화대사지표적변화,병측정요추、고골경、대조륭등부위BMD적차이。결과：여치료전상비교,치료후환자Ca、ALP、UCa명현하강,요추、고골경、대조륭등부위BMD명현상승,유현저적통계학차이(P<0.05)。치료전후P、UP비교,무통계학차이(P>0.05)。결론：재항갑항약물치료기출상보충유생소D、개제화아륜련산납,가조절갑항환자골대사,연완골질소송진정,구유적겁적림상의의。
Objective:Observe the change of bone density and bone metabolic biochemical indexes before and after treatment in hyperthyroidism,for clinical reference.Methods:Choose 74 cases in Jan. to Dec. 2010 in our hospital,give methimazole,vitamin D,calcium lactate,sodium alendronate.1 year later,observe changes of Ca,P,ALP,UCa,UP before and after treatment,and determinate BMD of lumbar spine,femoral neck,and trochanter.Results:Compared with before treatment,Ca, ALP,UCa decreased after treatment,BMD of lumbar spine,femoral neck,trochanter increased,has statistically significant difference (P<0.05).Comparison of P,UP before and after treatment,has no significant difference (P>0.05).Conclusion:On the basis of antithyroid drug therapy,vitamin D,calcium and sodium alendronate,can regulate bone metabolism of hyperthyroidism,delay the process of osteoporosis,has positive clinical significance.