CAJ | 학술논문

　　目的：评价盐酸法舒地尔和甘露醇联合治疗颅脑肿瘤术后脑水肿的疗效及安全性。方法：2009年1月~2011年12月复旦大学附属华山医院东院40例颅脑肿瘤术后脑水肿患者，随机分为治疗组和对照组各20例。治疗组应用盐酸法舒地尔和甘露醇联合治疗；对照组应用甘露醇进行治疗。评价两组治疗前及治疗后7天的脑水肿范围和神经功能缺损评分。结果：治疗后7天治疗组脑水肿缩小范围较对照组明显(P<0.01)，降低神经功能缺损评分也较对照组明显(P<0.01)，治疗组较对照组未增加不良反应。结论：盐酸法舒地尔和甘露醇联合治疗能有效改善颅脑肿瘤术后脑水肿，降低神经功能缺损评分。
　　목적：평개염산법서지이화감로순연합치료로뇌종류술후뇌수종적료효급안전성。방법：2009년1월~2011년12월복단대학부속화산의원동원40례로뇌종류술후뇌수종환자，수궤분위치료조화대조조각20례。치료조응용염산법서지이화감로순연합치료；대조조응용감로순진행치료。평개량조치료전급치료후7천적뇌수종범위화신경공능결손평분。결과：치료후7천치료조뇌수종축소범위교대조조명현(P<0.01)，강저신경공능결손평분야교대조조명현(P<0.01)，치료조교대조조미증가불량반응。결론：염산법서지이화감로순연합치료능유효개선로뇌종류술후뇌수종，강저신경공능결손평분。
Objective:To study the curative effect and safety of the combined therapy of fasudil hydrochloride and mannitol on encephaledema after craniotoma of cerebral tumor.Methods:Random allocation was taken to averagely divide 40 patients with encephaledema after craniotoma of cerebral tumor into two groups: treatment group (n=20) and control group (n=20).Patients were in treatment group adapting combined intravenous injection therapy with fasudil hydrochloride and mannitol.Other cases were in control group adapting intravenous injection therapy with mannitol.The range of the brain edema and the neurological severity score were assessed before treatment and seven days after treatment. Results:The brain edema volume reduced significantly in the treatment group comparing with that in the control group (P<0.01).The neurological severity scores also reduced significantly in the treatment group comparing with that in the control group.Adverse reactions did not increase in the treatment group comparing with that in the control group. Conclusion:The combined therapy with fasudil hydrochloride and mannitol could improve the encephaledema and reduce the neurological severity scores.