CAJ | 학술논문

　　神经内分泌肿瘤(neuroendocrine neoplasm，NEN)是一组起源于肽能神经元和神经内分泌细胞的异质性肿瘤。2010年第4版《世界卫生组织(World Health Organization，WHO)消化系统肿瘤分类》对NEN的命名、分类和分级进行修订和统一，纠正以往NEN诊断名称使用的混乱、规范NEN的病理分类和分级，增加NEN诊断的互认性，为NEN的临床治疗、预后判断提供必要的病理学信息。病理医师在常规病理诊断报告时应当按照一定的步骤要求，结合免疫组织化学染色结果进行准确的诊断、分类和分级，并提供临床分期必需的病理参数。近年来，有关NEN的临床和基础研究结果，使学者们对2010年第四版《WHO消化系统肿瘤分类》的部分内容和分级标准有了新的认识，提出了新观点，一些数据有待于进一步的大样本探讨证实。
　　신경내분비종류(neuroendocrine neoplasm，NEN)시일조기원우태능신경원화신경내분비세포적이질성종류。2010년제4판《세계위생조직(World Health Organization，WHO)소화계통종류분류》대NEN적명명、분류화분급진행수정화통일，규정이왕NEN진단명칭사용적혼란、규범NEN적병리분류화분급，증가NEN진단적호인성，위NEN적림상치료、예후판단제공필요적병이학신식。병리의사재상규병리진단보고시응당안조일정적보취요구，결합면역조직화학염색결과진행준학적진단、분류화분급，병제공림상분기필수적병리삼수。근년래，유관NEN적림상화기출연구결과，사학자문대2010년제사판《WHO소화계통종류분류》적부분내용화분급표준유료신적인식，제출료신관점，일사수거유대우진일보적대양본탐토증실。
Neuroendocrine neoplasm (NEN)is a group of heterogeneous tumors originated from the peptidergic neurons and neuroendocrine cells. A revised system of classification, nomenclature and grading of NEN was proposed by the fourth edition of“World Health Organization classification of tumours of the digestive system”in 2010. It apparently contributes to unify the method of classification, put an end of the confusion in nomenclature, standardize the grading system and predict the outcomes more accurately. With the combination of the results by immunohistochemical studies, pathologists should be in accordance with the requirements to make a diagnosis of NEN with accurate classification, grading and the pathological parameters essential to staging. Recently, new advances in NEN study put forward a new view in the classification and grading system that will lead to the updates of the diagnostic system after further studies on a large scale of samples.