CAJ | 학술논문

　　目的探讨在重症急性胰腺炎(severe acute pancreatitis，SAP)大鼠血清中Chemerin、C反应蛋白(C-reative protein， CRP)、肿瘤坏死因子α(TNF-α)水平的变化。方法胆胰管内注射5%牛黄胆酸钠造模。将动物随机分为对照组、假手术组、重症急性胰腺炎组，各组于术后12 h时间点处死动物，处死前抽血测血清淀粉酶、Chemerin、TNF-α、CRP水平，同时取处死大鼠的胰腺组织，测定胰腺/体重比值，行HE染色，观察大鼠胰腺组织病理变化。结果 SAP组血清Chemerin、CRP、TNF-α水平较正常对照组、假手术组均明显升高(P＜0.01)。血清Chemerin、CRP、TNF-α水平改变与胰腺组织病理评分呈正相关(r=0.802、0.785，0.769，P＜0.01)。结论 Chemerin可能与重症急性胰腺炎的发生、发展有关，可作为早期预测急性胰腺炎严重程度的有效指标之一。
　　목적탐토재중증급성이선염(severe acute pancreatitis，SAP)대서혈청중Chemerin、C반응단백(C-reative protein， CRP)、종류배사인자α(TNF-α)수평적변화。방법담이관내주사5%우황담산납조모。장동물수궤분위대조조、가수술조、중증급성이선염조，각조우술후12 h시간점처사동물，처사전추혈측혈청정분매、Chemerin、TNF-α、CRP수평，동시취처사대서적이선조직，측정이선/체중비치，행HE염색，관찰대서이선조직병리변화。결과 SAP조혈청Chemerin、CRP、TNF-α수평교정상대조조、가수술조균명현승고(P＜0.01)。혈청Chemerin、CRP、TNF-α수평개변여이선조직병리평분정정상관(r=0.802、0.785，0.769，P＜0.01)。결론 Chemerin가능여중증급성이선염적발생、발전유관，가작위조기예측급성이선염엄중정도적유효지표지일。
Objective To study the serum levels of chemerin, CRP and TNF-αin rats with severe acute pancreatitis (SAP). Methods A SAP model was established by injecting 5%sodium taurocholate into the cholangiopancreatic duct. Thirty rats were randomly divided into control group, sham operation group) and SAP group (10 in each group). The rats were killed at 12 h after operation. Their serum levels of amylase, chemerin, CRP and TNF-αwere measured. The pancreas/BMI ratio was calculated. Lesions in pancreatic tissue of rats were observed with HE staining. Results The serum levels of chemerin, TNF-α, and CRP were significantly higher in SAP group than in control group and sham operation group (P<0.01) and positively related with the pathological pancreatic tissue score (r=0.802, 0.785, 0.769, P<0.01). Conclusion Chemerin may be related with the occurrence and progress of SAP and can be used as one of the important indications for predicting the severity of early SAP.