CAJ | 학술논문

　　目的探讨应用计算流体动力学(computational fluid dynamics，CFD)技术构建个体化正常人冠状动脉血流动力学模型的方法，探索冠脉局部血流动力学参数分布情况及各参数与冠状动脉粥样硬化病变的关系。方法以CT图像为基础进行冠状动脉三维几何建模，构建个体化冠状动脉血流动力学模型，对正常人体左冠状动脉前降支局部进行数值模拟，应用有限体积法进行血流数值模拟。结果获得个体化正常左冠状动脉前降支血管树模型及血流动力学参数，数值模拟结果包括冠状动脉的血液流场、壁面压力(wall pressure，WP)、壁面切应力(wall shear stress，WSS)分布，可见各参数呈不规则分布，在血管弯曲分叉部位靠近管壁处血流明显减速、血管发出分支区域出现高WP、WSS分布，而这些区域的对侧血管壁对应不均匀的低WP、WSS分布。结论以CT图像为基础的数值模拟技术可以重建个体化冠状动脉血流动力学模型，为分析血流动力学参数与冠状动脉粥样硬化形成的关系提供研究手段。
　　목적탐토응용계산류체동역학(computational fluid dynamics，CFD)기술구건개체화정상인관상동맥혈류동역학모형적방법，탐색관맥국부혈류동역학삼수분포정황급각삼수여관상동맥죽양경화병변적관계。방법이CT도상위기출진행관상동맥삼유궤하건모，구건개체화관상동맥혈류동역학모형，대정상인체좌관상동맥전강지국부진행수치모의，응용유한체적법진행혈류수치모의。결과획득개체화정상좌관상동맥전강지혈관수모형급혈류동역학삼수，수치모의결과포괄관상동맥적혈액류장、벽면압력(wall pressure，WP)、벽면절응력(wall shear stress，WSS)분포，가견각삼수정불규칙분포，재혈관만곡분차부위고근관벽처혈류명현감속、혈관발출분지구역출현고WP、WSS분포，이저사구역적대측혈관벽대응불균균적저WP、WSS분포。결론이CT도상위기출적수치모의기술가이중건개체화관상동맥혈류동역학모형，위분석혈류동역학삼수여관상동맥죽양경화형성적관계제공연구수단。
Objective To study the local coronary artery parameters and their relation with coronary atherosclerosis by establishing the normal coronary artery hemodynamics model using computational fluid dynamics (CFD) techniques. Methods A 3D geometric model of coronary artery hemodynamics was established according to the CT images. Numerical value was simulated for the anterior descending branch of normal left coronary artery and blood flow value was simulated with the finite volume. Results The anterior descending branch model of normal left coronary artery tree was established and its hemodynamic parameters were displayed, including streamlines of blood velocity, wall pressure (WP), and wall shear stress (WSS). The parameters were irregularly distributed. The blood flow velocity was significantly lower at the outer walls of bifurcations with high WP and WSS, and low WP and WSS at the opposite side of vascular walls. Conclusion CT image-based numerical value simulation technique can be used in establishing coronary artery hemodynamics model, and in analyzing the relation between hemodynamics parameters and coronary atherosclerosis.