CAJ | 학술논문

　　目的分析糖尿病周围神经病变(diabetic peripheral neuropathy，DPN)的临床与电生理特点。方法对2010年9月-2012年5月在武警总医院住院治疗的84例糖尿病周围神经病变患者的临床资料及电生理检测结果进行回顾性分析。结果神经电生理中感觉神经传导异常程度重于运动神经，波幅的下降程度较传导速度减慢明显，下肢重于上肢(P均＜0.05)；皮肤交感反射检测下肢的异常率高于上肢(P＜0.01)；糖尿病周围神经病变最常见的临床症状为肢体麻木；最常见的体征是感觉减退；神经传导异常组的病程、血糖及糖化血红蛋白水平均高于神经传导正常组(P＜0.05)。结论 DPN的临床和电生理表现均以感觉神经受损为主；早期通过神经电生理诊断时要同时行神经传导和皮肤交感反应检测；病程越长，血糖控制水平越差，神经电生理结果出现异常的可能性越大。
　　목적분석당뇨병주위신경병변(diabetic peripheral neuropathy，DPN)적림상여전생리특점。방법대2010년9월-2012년5월재무경총의원주원치료적84례당뇨병주위신경병변환자적림상자료급전생리검측결과진행회고성분석。결과신경전생리중감각신경전도이상정도중우운동신경，파폭적하강정도교전도속도감만명현，하지중우상지(P균＜0.05)；피부교감반사검측하지적이상솔고우상지(P＜0.01)；당뇨병주위신경병변최상견적림상증상위지체마목；최상견적체정시감각감퇴；신경전도이상조적병정、혈당급당화혈홍단백수평균고우신경전도정상조(P＜0.05)。결론 DPN적림상화전생리표현균이감각신경수손위주；조기통과신경전생리진단시요동시행신경전도화피부교감반응검측；병정월장，혈당공제수평월차，신경전생리결과출현이상적가능성월대。
Objective To analyze the clinical and electrophysiological features in patients with diabetic peripheral neuropathy (DPN). Methods Clinical data about 84 DPN patients who underwent neuroelectrophysiologic test in General Hospital of Armed Police Forces from September 2010 to May 2012 were retrospectively analyzed. Results Neuroelectrophysiologic test showed that the abnormal rate of sensory nerve conduction was higher than that of motor nerve conduction (P<0.05), the amplitude was lower than conduction velocity and higher in lower extremities than in upper extremities (P<0.05), and the abnormal rate of skin sympathetic reflect was higher in lower extremities than in upper extremities (P < 0.01). Limb numbness and hypoesthesia were the most common clinical symptom and sign in DPN patients. The course of DPN, blood glucose and glycosylated hemoglobin levels were higher in patients with abnormal nerve conduction than in those with normal nerve conduction (P < 0.05). Conclusion Sensory nerve injury is the most common clinical and neuroelectrophysiologic manifestation in DPN patients. DPN should be diagnosed according to electrophysiological test, nerve conduction and skin sympathetic reflect. The longer the course of DPN is, the poorer the blood glucose control level is, and the worse the neuroelectrophysiologic test is.