CAJ | 학술논문

　　目的对冠心病合并代谢综合征(metabolic syndrome，MS)的患者脂质和载脂蛋白水平进行分析。方法选择于2011年5月-2012年10月在我院心内科行冠状动脉造影术并确诊为冠心病的患者119例，分为合并MS组(53例)和未合并MS组(66例)，比较两组相关危险因素，测定血清脂质水平和载脂蛋白谱，分析冠心病合并MS患者血脂的特点。结果与未合并MS组比较，冠心病合并MS组甘油三酯(TG)、载脂蛋白B(ApoB)、载脂蛋白C2(ApoC2)、载脂蛋白C3(ApoC3)水平均增高(P＜0.05~0.01)；高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(ApoA1)水平低于未合并MS组(P＜0.05~<0.01)；两组冠心病患者总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A2(ApoA2)、载脂蛋白E(ApoE)水平比较无统计学差异(P＞0.05)；冠心病合并MS组冠脉病变严重程度明显增加(P＜0.01)。结论冠心病患者合并MS存在多种脂质代谢紊乱，并可加重冠状动脉病变严重程度。
　　목적대관심병합병대사종합정(metabolic syndrome，MS)적환자지질화재지단백수평진행분석。방법선택우2011년5월-2012년10월재아원심내과행관상동맥조영술병학진위관심병적환자119례，분위합병MS조(53례)화미합병MS조(66례)，비교량조상관위험인소，측정혈청지질수평화재지단백보，분석관심병합병MS환자혈지적특점。결과여미합병MS조비교，관심병합병MS조감유삼지(TG)、재지단백B(ApoB)、재지단백C2(ApoC2)、재지단백C3(ApoC3)수평균증고(P＜0.05~0.01)；고밀도지단백담고순(HDL-C)、재지단백A1(ApoA1)수평저우미합병MS조(P＜0.05~<0.01)；량조관심병환자총담고순(TC)、저밀도지단백담고순(LDL-C)、재지단백A2(ApoA2)、재지단백E(ApoE)수평비교무통계학차이(P＞0.05)；관심병합병MS조관맥병변엄중정도명현증가(P＜0.01)。결론관심병환자합병MS존재다충지질대사문란，병가가중관상동맥병변엄중정도。
Objective To analyze the serum levels of lipid and apolipoprotein (Apo) in coronary heart disease (CHD) patients with metabolic syndrome (MS). Methods One hundred and nineteen CHD patients, who underwent coronary arteriography in our hospital from May 2011 to October 2012, were divided into CHD with MS group (n=53) and CHD without MS group (n=66). Risk factors for CHD were compared between the two groups. Their serum levels of lipid and Apo were measured. Characteristics of lipid profile in CHD patients with MS were analyzed. Results The serum levels of TG, ApoB, ApoC2 and ApoC3 were significantly higher whereas that of HDL-C and ApoA1 were significantly lower in CHD with MS group than in CHD without MS group (P<0.05-<0.01). No significant difference was found in TC, LDL-C, ApoA2 and ApoE between the two groups (P >0.05). The coronary artery lesion was severer in CHD with MS group than in CHD without MS group (P<0.01). Conclusion CHD patients with MS suffer from multiple lipid metabolic disorders which can aggravate their coronary artery lesions.