CAJ | 학술논문

　　目的研究10年间住院慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)患者脑卒中患病比例、人群分布、年龄和性别的相关性。方法对2000年1月-2010年3月间解放军总医院、北京协和医院及北京医院的住院病案数据库进行现况调查分析。结果入选住院患者共46701例，其中COPD 4960例，占10.62%；COPD合并脑卒中808例，占16.29%，男性592例，女性216例，平均年龄(70.2±11.1)岁。各年龄段COPD男性患者患病比例均高于女性，并随年龄增长而升高；不同年龄(＜50岁、50~59岁、60~69岁、70~79岁及≥80岁)COPD的患病比例分别为1.81%、4.25%、7.97%、22.49%和41%。COPD患者发生脑卒中的风险明显高于非COPD患者(HR 2.97，95%CI 2.59%~3.40%)，男女COPD患者在脑卒中风险方面差异无统计学意义(P=0.372)。各年龄段COPD与非COPD患者脑卒中患病比例均有统计学差异(P均＜0.01)。结论 COPD是导致脑卒中发生和发展的重要危险因素之一。
　　목적연구10년간주원만성조새성폐질병(chronic obstructive pulmonary disease，COPD)환자뇌졸중환병비례、인군분포、년령화성별적상관성。방법대2000년1월-2010년3월간해방군총의원、북경협화의원급북경의원적주원병안수거고진행현황조사분석。결과입선주원환자공46701례，기중COPD 4960례，점10.62%；COPD합병뇌졸중808례，점16.29%，남성592례，녀성216례，평균년령(70.2±11.1)세。각년령단COPD남성환자환병비례균고우녀성，병수년령증장이승고；불동년령(＜50세、50~59세、60~69세、70~79세급≥80세)COPD적환병비례분별위1.81%、4.25%、7.97%、22.49%화41%。COPD환자발생뇌졸중적풍험명현고우비COPD환자(HR 2.97，95%CI 2.59%~3.40%)，남녀COPD환자재뇌졸중풍험방면차이무통계학의의(P=0.372)。각년령단COPD여비COPD환자뇌졸중환병비례균유통계학차이(P균＜0.01)。결론 COPD시도치뇌졸중발생화발전적중요위험인소지일。
Objective To study the correlation of prevalence and distribution in patients with stroke due to chronic obstructive pulmonary disease (COPD) over the past 10 years with their age and gender. Methods Patients with stroke due to COPD admitted to Chinese PLA General Hospital, PUMC Hospital and Beijing Hospital from January 2000 to March 2010 were investigated according to the medical records databases. Results Of the 46 701 patients included in this study, 4 960 (10.62%) suffered from COPD. Of these 4 960 COPD patients (592 males and 216 females with an average age of 70.2±11.1 years, 808 (16.29%) were complicated with stroke. The prevalence of COPD was higher in male patients than in female patients and increased with their age. The prevalence of COPD was 1.81%, 4.25%, 7.97%, 22.49%and 41%respectively in the patients with their age<50, 50-59, 60-69, 70-79 and ≥ 80 years. The risk of stroke was significantly higher in COPD patients than in non-COPD patients (HR=2.97, 95%CI:2.59%-3.40%). No significant difference was observed in the prevalence of stroke among male and female COPD patients (P=0.372). However, a significant difference was found in the prevalence of stroke among COPD and non-COPD patients at different ages (P<0.01). Conclusion COPD is one of the important risk factor for the occurrence and development of stroke.