CAJ | 학술논문

　　目的探讨乳腺癌彩色多普勒超声表现与c-erbB-2表达的关系。方法151例乳腺癌患者，术前彩色多普勒超声检查，观察肿瘤大小、内部钙化、周边毛刺征、后方回声衰减、血流分级等表现；术后标本采用免疫组化法检测c-erbB-2表达情况。结果151例患者中c-erbB-2表达阳性71例（47．0％）；肿块超声表现：内部钙化、后方回声衰减、血流Ⅱ～Ⅲ级、有腋窝淋巴结转移与c-erbB-2表达有关（P＜0．05），而肿块大小、边缘有无毛刺征与c-erbB-2表达无明显相关性（P＞0．05）。结论乳腺癌彩色多普勒超声表现与c-erbB-2表达有关联，为临床诊疗计划的制订、预后的判断提供参考。
　　목적탐토유선암채색다보륵초성표현여c-erbB-2표체적관계。방법151례유선암환자，술전채색다보륵초성검사，관찰종류대소、내부개화、주변모자정、후방회성쇠감、혈류분급등표현；술후표본채용면역조화법검측c-erbB-2표체정황。결과151례환자중c-erbB-2표체양성71례（47．0％）；종괴초성표현：내부개화、후방회성쇠감、혈류Ⅱ～Ⅲ급、유액와림파결전이여c-erbB-2표체유관（P＜0．05），이종괴대소、변연유무모자정여c-erbB-2표체무명현상관성（P＞0．05）。결론유선암채색다보륵초성표현여c-erbB-2표체유관련，위림상진료계화적제정、예후적판단제공삼고。
Objective To investigate the relationship between images of color Doppler ultrasonography and c-erbB-2 express in patients with breast cancer .Methods One hundred and fifty-one patients with breast cancer were detected by color Doppler ultrasonography to observe tumor size ,internal calcification,perimeter burr sign,rear echo attenuation,blood flow classification.The postoperative samples were detected for c-erbB-2 expression by immunohistochemical method.Results There were 71 cases of positive expression of c-erbB-2 in 151 patients(47.0%).Ultrasound images of tumors showed that internal calcification ,rear echo attenuation,blood flow of grade Ⅱ-Ⅲ and axillary lymph node metastases correlated with c-erbB-2 expression(P<0.05),and tumor size and perimeter burr sign didn′t correlated with c-erbB-2 expression significantly(P>0.05).Conclusion The images of color Doppler ultrasonography correlate with c-erbB-2 expression in patients with breast cancer ,which can provide valuable reference for clinical diagnosis plan , treatment and judgment of prognosis .