CAJ | 학술논문

　　目的探讨古钩藤水提液对小鼠实验性高血糖的影响。方法建立链脲佐菌素和四氧嘧啶诱导小鼠高血糖模型，按高、中、低剂量的古钩藤水提液灌胃给药，空白对照组和模型对照组给予等体积的生理盐水，阳性对照组给予盐酸二甲双胍、格列本脲，观察给药后小鼠血糖的变化。结果给药前模型对照组、格列本脲组、古钩藤高剂量组、中剂量组、低剂量组5组之间血糖值比较，差异无统计学意义（P＞0．05）；给药后古钩藤高剂量组、中剂量组、低剂量组血糖值均明显低于链脲佐菌素模型对照组（P＜0．05）。给药前模型对照组、二甲双胍组，以及古钩藤高剂量组、中剂量组、低剂量组5组之间血糖值比较，差异无统计学意义（P＞0．05）；给药后古钩藤高剂量组、中剂量组、低剂量组血糖值均明显低于四氧嘧啶模型对照组（P＜0．05）。结论古钩藤水提液对链脲佐菌素致高血糖小鼠和四氧嘧啶致高血糖小鼠都有显著降血糖作用。
　　목적탐토고구등수제액대소서실험성고혈당적영향。방법건립련뇨좌균소화사양밀정유도소서고혈당모형，안고、중、저제량적고구등수제액관위급약，공백대조조화모형대조조급여등체적적생리염수，양성대조조급여염산이갑쌍고、격렬본뇨，관찰급약후소서혈당적변화。결과급약전모형대조조、격렬본뇨조、고구등고제량조、중제량조、저제량조5조지간혈당치비교，차이무통계학의의（P＞0．05）；급약후고구등고제량조、중제량조、저제량조혈당치균명현저우련뇨좌균소모형대조조（P＜0．05）。급약전모형대조조、이갑쌍고조，이급고구등고제량조、중제량조、저제량조5조지간혈당치비교，차이무통계학의의（P＞0．05）；급약후고구등고제량조、중제량조、저제량조혈당치균명현저우사양밀정모형대조조（P＜0．05）。결론고구등수제액대련뇨좌균소치고혈당소서화사양밀정치고혈당소서도유현저강혈당작용。
Objective To investigate the effect of aqueous extracts from Cryptolepis buchananii Roem.et Schult.on blood glucose in mice with experimental hyperglycemia .Methods The mouse models of hyperglycaemia,induced by streptozotocin and alloxan respectively ,were established.The model mice were treated with a high-,medium-and low-dosage of aqueous extracts from Cryptolepis buchananii Roem.et Schult.by gavage(high-dosage group,medium-dosage group and low-dosage Cryptolepis buchananii Roem.et Schult.group).The mice in the blank control group and model control group were given the same volume of normal saline while the mice in the positive control group were given metformin HCL and glibenclamide.The changes of mice′blood glucose were observed among all groups after administration . Results There was no significant difference in the blood glucose level among model control group ,glibenclamide group, and high-,medium-and low-dosage Cryptolepis buchananii Roem.et Schult.groups before administration(P>0.05);After administration,the blood glucose levels in the high-,medium-and low-dosage Cryptolepis buchananii Roem.et Schult.groups were significantly lower than that in the streptozotocin-induced model control group (P<0.05).There was no significant difference in the blood glucose level among model control group,metformin HCL group,and high-,medium-and low-dosage Cryptolepis buchananii Roem.et Schult.groups before administration(P>0.05);After administration,the blood glucose levels in the high-,medium-and low-dosage Cryptolepis buchananii Roem.et Schult.groups were significantly lower than that in the alloxan-induced model control group(P<0.05).Conclusion Aqueous extracts of Cryptolepis buchananii Roem.et Schult.has significantly hypoglycemic effect on the mice with experimental hyperglycemia induced by alloxan or srteptozotonic.