CAJ | 학술논문

　　目的：观察丹芪六君颗粒对荷瘤鼠顺铂化疗后胃肠道不良反应的干预作用。方法：造模化疗后随机将90只荷瘤鼠分为空白组、西药组（胃复安+易蒙停）、中药组（丹芪六君颗粒），观察各组胃肠道症状变化情况及各组用药后疗效。结果：中药组与西药组控制化疗后小鼠胃肠道症状的有效率分别为76.7豫和50.0豫，两组比较差异有统计学意义（P<0.05）；中药组化疗后胃肠不良反应较西药组明显降低。结论：丹芪六君颗粒能较好缓解化疗后胃肠道不良反应，减轻腹胀、纳差、泄泻症状。
　　목적：관찰단기륙군과립대하류서순박화료후위장도불량반응적간예작용。방법：조모화료후수궤장90지하류서분위공백조、서약조（위복안+역몽정）、중약조（단기륙군과립），관찰각조위장도증상변화정황급각조용약후료효。결과：중약조여서약조공제화료후소서위장도증상적유효솔분별위76.7예화50.0예，량조비교차이유통계학의의（P<0.05）；중약조화료후위장불량반응교서약조명현강저。결론：단기륙군과립능교호완해화료후위장도불량반응，감경복창、납차、설사증상。
Objective: To observe the effect of Danqi Liujun granules on gastrointestinal reaction of tumor-bearing mice after chemotherapy with DDP. Methods: Ninety tumor-bearing mice that were treated with chemotherapy with DDP were randomly divided into 3 groups: blank control, western medicine(metoclopraide+loperamide hydrocloride) group, and Danqi Liujun granule group, 30 mice in each. Gastrointestinal side effects and therapeutic effects were observed among groups. Results: The total effective rates of western medicine group and Danqi Liujun granule group were 76.7% and 50.0%, respectively, with a significant difference between them (P<0.05). Gastrointestinal side effects after chemotherapy with DDP were dramatically milder in Danqi Liujun granule group as compared with that in western medicine group. Conclusion: Danqi Liujun granules can markedly alleviate adverse reaction of stom-ach, including abdominal distension, bad appetite, and diarrhea.