国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2013年
3期
100-105
,共6页
黄容海%蒋力%张珂%鲁岩%赫嵘%丁振昊%李勤涛%郭立民%李宝亮
黃容海%蔣力%張珂%魯巖%赫嶸%丁振昊%李勤濤%郭立民%李寶亮
황용해%장력%장가%로암%혁영%정진호%리근도%곽립민%리보량
慢性乙型肝炎%脂联素%受体%代谢综合征%胰岛素抵抗
慢性乙型肝炎%脂聯素%受體%代謝綜閤徵%胰島素牴抗
만성을형간염%지련소%수체%대사종합정%이도소저항
Chronic hepatitis B%Adiponectin%Receptor%Metabolic syndrome%Insulin resistance
目的 研究脂联素及其受体2与慢性乙型肝炎感染伴发MS患者的肝脂肪变、纤维化和炎症的相关性.方法 收集138例慢性乙型肝炎(chronic hepatitis B,CHB)患者资料,根据患者有无代谢综合征(metabolic syndrome,MS)分为MS组(65例)和非MS组(73例),检测两组患者血清脂联素(adiponectin,Adi)水平,并比较血清酶学、糖脂类代谢相关指标水平以及HBeAg阳性率等指标是否有组间差异.结果 CHB伴发MS患者血清酶学、糖脂类代谢相关指标水平以及HBeAg阳性率明显高于非MS组.体重指数和稳态模型评估指数是CHB伴发MS患者的独立危险因素.结论 CHB患者伴发的MS与胰岛素抵抗相关,肝脏脂联素表达水平与CHB伴发MS患者疾病进展密切相关.
目的 研究脂聯素及其受體2與慢性乙型肝炎感染伴髮MS患者的肝脂肪變、纖維化和炎癥的相關性.方法 收集138例慢性乙型肝炎(chronic hepatitis B,CHB)患者資料,根據患者有無代謝綜閤徵(metabolic syndrome,MS)分為MS組(65例)和非MS組(73例),檢測兩組患者血清脂聯素(adiponectin,Adi)水平,併比較血清酶學、糖脂類代謝相關指標水平以及HBeAg暘性率等指標是否有組間差異.結果 CHB伴髮MS患者血清酶學、糖脂類代謝相關指標水平以及HBeAg暘性率明顯高于非MS組.體重指數和穩態模型評估指數是CHB伴髮MS患者的獨立危險因素.結論 CHB患者伴髮的MS與胰島素牴抗相關,肝髒脂聯素錶達水平與CHB伴髮MS患者疾病進展密切相關.
목적 연구지련소급기수체2여만성을형간염감염반발MS환자적간지방변、섬유화화염증적상관성.방법 수집138례만성을형간염(chronic hepatitis B,CHB)환자자료,근거환자유무대사종합정(metabolic syndrome,MS)분위MS조(65례)화비MS조(73례),검측량조환자혈청지련소(adiponectin,Adi)수평,병비교혈청매학、당지류대사상관지표수평이급HBeAg양성솔등지표시부유조간차이.결과 CHB반발MS환자혈청매학、당지류대사상관지표수평이급HBeAg양성솔명현고우비MS조.체중지수화은태모형평고지수시CHB반발MS환자적독립위험인소.결론 CHB환자반발적MS여이도소저항상관,간장지련소표체수평여CHB반발MS환자질병진전밀절상관.
Objective To assess the relationship between adiponectin,its receptors and hepatic steatosis,firosis,inflmmation in patients of chronic hepatitis B (CHB) with metabolic syndrome (MS).Methods We studied 138 patients with chronic hepatitis B (CHB),who were from Beijing Ditan hospital from January 2005 to December 2012.According to whether being diagnosd with MS,two groups (65 with MS vs 73 without MS) were established.They were compared with demographic,biochemical,metabolic,and histological characteristics.The serum adiponectin level of patients were detected.Results In the group of CHB patients with MS,the levels of LDH,γ-GT,FPG,FINS,HOMA-IR,HOMA-β,TG,and HBeAg positive rate were significantly higher than those in the group without MS.With binary logistic regression analyses,BMI and HOMA-IR showed independent predictors to MS in patients with CHB.Conclusions The CHB patients with MS showed more severe steatosis,CHB showed insulin resistance.Reduced serum levels of adiponectin might be relevance in CHB patients with MS.These findings indicated that reduced liver adiponectin expression may play an important role in the pathogenesis and progression of CHB patients with MS.
