中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
28期
10-13
,共4页
曾宇然%王伟鸿%卢敏%严丽君
曾宇然%王偉鴻%盧敏%嚴麗君
증우연%왕위홍%로민%엄려군
透析%血小板源性生长因子%动脉粥样硬化
透析%血小闆源性生長因子%動脈粥樣硬化
투석%혈소판원성생장인자%동맥죽양경화
Dialysis%Platelet-derived growth factor%Atherosclerosis
目的 测定血液透析患者血浆血小板源性生长因子BB(PDGF-BB)水平,探讨其在血液透析患者颈动脉粥样硬化发生发展中的意义.方法 选择36例维持性血液透析患者作为试验组及性别、年龄相匹配的20例健康体检者作为健康对照组,采用酶联免疫吸附试验法测定两组血浆PDGF-BB水平,同时应用彩色多普勒超声显像仪检查两组颈动脉内膜-中层厚度(IMT)及所探测到的斑块情况,并进行统计学分析.结果 试验组颈动脉IMT为(1.01 ±0.23) mm,颈动脉粥样硬化阳性率为69.4％ (25/36)；健康对照组颈动脉IMT为(0.72 ±0.15) mm,颈动脉粥样硬化阳性率为10.0％(2/20).试验组颈动脉IMT及颈动脉粥样硬化阳性率均显著高于健康对照组,差异有统计学意义(P＜0.01).试验组血浆肌酐、白蛋白、总胆固醇较健康对照组显著增高[(1991.8±228.6)μmol/L比(71.2±15.9)μmol/L、(36.78±3.40)g/L比(41.96±2.07) g/L、(4.97±0.57) mmol/L比(4.48±0.84) mmol/L],差异有统计学意义(P＜0.01或＜0.05).试验组血浆PDGF-BB水平显著高于健康对照组[(93.27±31.58)ng/L比(31.71±15.78) ng/L],差异有统计学意义(P＜0.01).试验组中颈动脉粥样硬化阳性患者年龄、血浆PDGF-BB及三酰甘油水平均高于颈动脉粥样硬化阴性患者[(48.04±9.97)岁比(34.54±10.35)岁、(102.60±32.87) ng/L比(72.06±13.67) ng/L、(1.51±0.59) mmol/L比(1.01 ±0.27) mmol/L],差异有统计学意义(P＜0.01).回归分析显示,年龄(β=0.346,P＜ 0.01)、PDGF-BB(β=0.594,P＜ 0.01)为影响IMT的重要因素.结论 血液透析患者血浆PDGF-BB水平明显增高,其对颈动脉粥样硬化的发生有重要作用.
目的 測定血液透析患者血漿血小闆源性生長因子BB(PDGF-BB)水平,探討其在血液透析患者頸動脈粥樣硬化髮生髮展中的意義.方法 選擇36例維持性血液透析患者作為試驗組及性彆、年齡相匹配的20例健康體檢者作為健康對照組,採用酶聯免疫吸附試驗法測定兩組血漿PDGF-BB水平,同時應用綵色多普勒超聲顯像儀檢查兩組頸動脈內膜-中層厚度(IMT)及所探測到的斑塊情況,併進行統計學分析.結果 試驗組頸動脈IMT為(1.01 ±0.23) mm,頸動脈粥樣硬化暘性率為69.4％ (25/36)；健康對照組頸動脈IMT為(0.72 ±0.15) mm,頸動脈粥樣硬化暘性率為10.0％(2/20).試驗組頸動脈IMT及頸動脈粥樣硬化暘性率均顯著高于健康對照組,差異有統計學意義(P＜0.01).試驗組血漿肌酐、白蛋白、總膽固醇較健康對照組顯著增高[(1991.8±228.6)μmol/L比(71.2±15.9)μmol/L、(36.78±3.40)g/L比(41.96±2.07) g/L、(4.97±0.57) mmol/L比(4.48±0.84) mmol/L],差異有統計學意義(P＜0.01或＜0.05).試驗組血漿PDGF-BB水平顯著高于健康對照組[(93.27±31.58)ng/L比(31.71±15.78) ng/L],差異有統計學意義(P＜0.01).試驗組中頸動脈粥樣硬化暘性患者年齡、血漿PDGF-BB及三酰甘油水平均高于頸動脈粥樣硬化陰性患者[(48.04±9.97)歲比(34.54±10.35)歲、(102.60±32.87) ng/L比(72.06±13.67) ng/L、(1.51±0.59) mmol/L比(1.01 ±0.27) mmol/L],差異有統計學意義(P＜0.01).迴歸分析顯示,年齡(β=0.346,P＜ 0.01)、PDGF-BB(β=0.594,P＜ 0.01)為影響IMT的重要因素.結論 血液透析患者血漿PDGF-BB水平明顯增高,其對頸動脈粥樣硬化的髮生有重要作用.
목적 측정혈액투석환자혈장혈소판원성생장인자BB(PDGF-BB)수평,탐토기재혈액투석환자경동맥죽양경화발생발전중적의의.방법 선택36례유지성혈액투석환자작위시험조급성별、년령상필배적20례건강체검자작위건강대조조,채용매련면역흡부시험법측정량조혈장PDGF-BB수평,동시응용채색다보륵초성현상의검사량조경동맥내막-중층후도(IMT)급소탐측도적반괴정황,병진행통계학분석.결과 시험조경동맥IMT위(1.01 ±0.23) mm,경동맥죽양경화양성솔위69.4％ (25/36)；건강대조조경동맥IMT위(0.72 ±0.15) mm,경동맥죽양경화양성솔위10.0％(2/20).시험조경동맥IMT급경동맥죽양경화양성솔균현저고우건강대조조,차이유통계학의의(P＜0.01).시험조혈장기항、백단백、총담고순교건강대조조현저증고[(1991.8±228.6)μmol/L비(71.2±15.9)μmol/L、(36.78±3.40)g/L비(41.96±2.07) g/L、(4.97±0.57) mmol/L비(4.48±0.84) mmol/L],차이유통계학의의(P＜0.01혹＜0.05).시험조혈장PDGF-BB수평현저고우건강대조조[(93.27±31.58)ng/L비(31.71±15.78) ng/L],차이유통계학의의(P＜0.01).시험조중경동맥죽양경화양성환자년령、혈장PDGF-BB급삼선감유수평균고우경동맥죽양경화음성환자[(48.04±9.97)세비(34.54±10.35)세、(102.60±32.87) ng/L비(72.06±13.67) ng/L、(1.51±0.59) mmol/L비(1.01 ±0.27) mmol/L],차이유통계학의의(P＜0.01).회귀분석현시,년령(β=0.346,P＜ 0.01)、PDGF-BB(β=0.594,P＜ 0.01)위영향IMT적중요인소.결론 혈액투석환자혈장PDGF-BB수평명현증고,기대경동맥죽양경화적발생유중요작용.
Objective To measure the level of platelet derived growth factor-BB (PDGF-BB) in maintenance hemodialysis patients and investigate the significance of carotid atherosclerosis.Methods Thirty-six maintenance hemodialysis patients (test group) and 20 healthy controls (normal control group) were enrolled in this study.The level of PDGF-BB was measured by enzyme-linked immunosorbent assay in two groups.Intima-media thickness (IMT) and atherosclerotic plaques of the extracranial common carotid artery were measured by echocardiography.Results The level of IMT and the positive rate of carotid atherosclerosis in test group were significantly higher than those in normal control group [(1991.8 ± 228.6) μ mol/L vs.(71.2± 15.9) μmol/L,(36.78 ±3.40) g/Lvs.(41.96±2.07) g/L,(4.97 ±0.57) mmol/Lvs.(4.48 ±0.84) mmol/L][(1.01 ±0.23) mm vs.(0.72 ±0.15) mm,69.4％(25/36) vs.10.0％(2/20)](P＜ 0.01).The level of plasma creatinine,albumin and total cholesterol in test group were significantly higher than those in normal control group (P ＜ 0.01 or ＜ 0.05).The level of PDGF-BB in test group was significantly higher than that in normal control group[(93.27 ± 31.58) ng/L vs.(31.71 ± 15.78) ng/L,P ＜ 0.01].In test group,age and the level of PDGF-BB and triacylglycerol in carotid atherosclerosis patients were significantly higher than those in non-carotid atherosclerosis patients [(48.04 ± 9.97) years vs.(34.54 ± 10.35) years,(102.60 ± 32.87) ng/L vs.(72.06 ± 13.67) ng/L,(1.51 ± 0.59) mmol/L vs.(1.01 ± 0.27) mmol/L] (P ＜ 0.01).Regression analysis showed that age (β =0.346,P ＜ 0.01) and PDGF-BB (β =0.594,P＜ 0.01) were the important impacting factors for IMT.Conclusion The level of PDGF-BB is increased in maintenance hemodialysis patients,and it may play an important role in carotid atherosclerosis.
