CAJ | 학술논문

　　目的：制备出符合要求的仙灵骨葆分散片制剂，进行制备工艺研究。方法以分散片均匀性、片子的硬度、脆碎度等为指标，比较了不同处方及工艺如不同种类及比例的崩解剂、稀释剂、粘合剂及不同的压片工艺等。结果：崩解剂为交联聚乙烯吡咯烷酮(交联PVP)；稀释剂为微粉硅胶；粘合剂为80%乙醇；硬度控制为4～8 kg；颗粒粒度为24目；水分少于4.0%。结论：该工艺生产出来的产品各项指标均能符合规定。
　　목적：제비출부합요구적선령골보분산편제제，진행제비공예연구。방법이분산편균균성、편자적경도、취쇄도등위지표，비교료불동처방급공예여불동충류급비례적붕해제、희석제、점합제급불동적압편공예등。결과：붕해제위교련취을희필각완동(교련PVP)；희석제위미분규효；점합제위80%을순；경도공제위4～8 kg；과립립도위24목；수분소우4.0%。결론：해공예생산출래적산품각항지표균능부합규정。
Objectlve: To make the qualified Xianling Gubao Dispersible Tablets, we carried out a detailed research. Methods: With dispersal uniformaity, rigidity, brittleness as the targets, we compared different kind ingrents (such as different dispersants, thinners, emplasties) and preparation process. Results:We chose PPVP, SiO2, 80%Ethanol, birttleness under 4~8 kg, granularity 24 mesh , moisture under 4.0%. Conclusion:The mass trail products made accord to the best preparation meet to the legal regulations. The process is operatale, repeatable and suitable to the batch manufatury.