CAJ | 학술논문

　　糖皮质激素(GC)主要是通过特异性受体(GR)参与的蛋白-蛋白相互作用(PPI)和蛋白-DNA相互作用(PDI)网络激活或抑制靶基因的转录。其中，GC干预Toll-like receptors(TLRs)信号网络时，主要依赖于增强TLR通路天然抑制因子表达、直接抑制TLR激活的转录调节因子以及交叉利用GR与TLR信号通路的必需辅助因子。笔者在总结GR的转录调节、TLRs信号网络以及GR与TLRs信号网络串扰的最新研究进展的基础上，着重评述了GR介导TLR信号通路的降调节机制，以期为深入揭示GC调节哺乳动物细胞功能的分子机制和临床应用提供参考。
　　당피질격소(GC)주요시통과특이성수체(GR)삼여적단백-단백상호작용(PPI)화단백-DNA상호작용(PDI)망락격활혹억제파기인적전록。기중，GC간예Toll-like receptors(TLRs)신호망락시，주요의뢰우증강TLR통로천연억제인자표체、직접억제TLR격활적전록조절인자이급교차이용GR여TLR신호통로적필수보조인자。필자재총결GR적전록조절、TLRs신호망락이급GR여TLRs신호망락천우적최신연구진전적기출상，착중평술료GR개도TLR신호통로적강조절궤제，이기위심입게시GC조절포유동물세포공능적분자궤제화림상응용제공삼고。
Glucocorticoid (GC) activates or inhibits the transcription of target genes mainly through the specific receptor-glucocorticoid receptor (GR) which involved in protein-protein interaction (PPI) and protein-DNA interaction (PDI) network. Meanwhile, the intervention of GC on Toll-like receptors (TLRs) signaling network largely depends on enhancing natural inhibitors of TLR pathways, the direct inhibition of the TLR-activated transcription factors and the required cofactors of cross-utilization of GR and TLR signaling pathways. In this article, the transcriptional regulation of GR, TLRs signaling networks and crosstalk of GR and TLRs signaling network were summarized based on the latest advances, and the GR-mediated mechanisms of down-regulation of TLR signaling pathways was reviewed in order to provide more valuable references on revealing the molecular mechanisms of the regulation of GC on mammalian cells and clinical application.