国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
7期
536-539
,共4页
碳酸酐酶Ⅲ%全身炎症反应综合征%氧化性应激%肺疾病,慢性阻塞性%肌,骨骼
碳痠酐酶Ⅲ%全身炎癥反應綜閤徵%氧化性應激%肺疾病,慢性阻塞性%肌,骨骼
탄산항매Ⅲ%전신염증반응종합정%양화성응격%폐질병,만성조새성%기,골격
Carbonic anhydrase Ⅲ%Systemic inflammatory reaction syndrome%Oxidative stress%Chronic obstructive pulmonary disease%Skeletal muscle
骨骼肌萎缩是 COPD 患者常见的全身症状，是导致 COPD 患者生活质量下降和病死率增加的主要危险因素。COPD 骨骼肌萎缩的形成机制非常复杂，与全身炎症反应、氧化应激、缺乏锻炼等因素有关。碳酸酐酶Ⅲ可能也参与了 COPD 患者骨骼肌萎缩的发生。上述刺激因素会降低骨骼肌氧化代谢能力，使肌蛋白分解/合成过程失衡、影响骨骼肌纤维的凋亡过程及改变肌纤维类型和氧化表型，导致骨骼肌功能障碍。
骨骼肌萎縮是 COPD 患者常見的全身癥狀，是導緻 COPD 患者生活質量下降和病死率增加的主要危險因素。COPD 骨骼肌萎縮的形成機製非常複雜，與全身炎癥反應、氧化應激、缺乏鍛煉等因素有關。碳痠酐酶Ⅲ可能也參與瞭 COPD 患者骨骼肌萎縮的髮生。上述刺激因素會降低骨骼肌氧化代謝能力，使肌蛋白分解/閤成過程失衡、影響骨骼肌纖維的凋亡過程及改變肌纖維類型和氧化錶型，導緻骨骼肌功能障礙。
골격기위축시 COPD 환자상견적전신증상，시도치 COPD 환자생활질량하강화병사솔증가적주요위험인소。COPD 골격기위축적형성궤제비상복잡，여전신염증반응、양화응격、결핍단련등인소유관。탄산항매Ⅲ가능야삼여료 COPD 환자골격기위축적발생。상술자격인소회강저골격기양화대사능력，사기단백분해/합성과정실형、영향골격기섬유적조망과정급개변기섬유류형화양화표형，도치골격기공능장애。
Skeletal muscle atrophy is common systemic symptom in patients with chronic obstructive pulmonary disease(COPD),it will become the major factor of the decrease of the quality of life and the increase of mortality rate in COPD patients.The mechanism of skeletal muscle atrophy in COPD is very complex,that involves systemic inflammatory reaction,oxidative stress,lack of exercise,etc factors.Carbonic anhydrase Ⅲ may also involve in this mechanism.These stimulus will decrease skeletal muscle oxidative metabolism capacity,make a disbalance between muscle protein degradation and synthesis,influence skeletal muscle fiber apoptosis process and change the muscle fiber type and oxidation phenotype,and finally resulting in skeletal muscle atrophy.
