国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2012年
10期
751-756
,共6页
卒中%脑缺血%基因组学%遗传相关性研究%全基因组关联研究%多态现象,单核苷酸%危险因素
卒中%腦缺血%基因組學%遺傳相關性研究%全基因組關聯研究%多態現象,單覈苷痠%危險因素
졸중%뇌결혈%기인조학%유전상관성연구%전기인조관련연구%다태현상,단핵감산%위험인소
Stroke%Brain Ischemia%Genomics%Genetic Association Studies%Genome-Wide Association Study%Polymorphism,Single Nucleotide%Risk Factors
缺血性卒中是导致成年人残疾和死亡的主要疾病之一.年龄、性别、吸烟、高血压和糖尿病等是缺血性卒中的危险因素,但它们仅能部分解释卒中发病的原因.孪生子、家系以及单基因遗传性卒中研究显示,缺血性卒中具有明显的遗传倾向性.近年来,基因组学在缺血性卒中研究中取得了明显进展,并显示许多新的单核苷酸多态性或基因与缺血性卒中及其危险因素有关.然而,这些遗传基因对缺血性卒中的贡献仍然太小,需要重复性研究进一步证实.
缺血性卒中是導緻成年人殘疾和死亡的主要疾病之一.年齡、性彆、吸煙、高血壓和糖尿病等是缺血性卒中的危險因素,但它們僅能部分解釋卒中髮病的原因.孿生子、傢繫以及單基因遺傳性卒中研究顯示,缺血性卒中具有明顯的遺傳傾嚮性.近年來,基因組學在缺血性卒中研究中取得瞭明顯進展,併顯示許多新的單覈苷痠多態性或基因與缺血性卒中及其危險因素有關.然而,這些遺傳基因對缺血性卒中的貢獻仍然太小,需要重複性研究進一步證實.
결혈성졸중시도치성년인잔질화사망적주요질병지일.년령、성별、흡연、고혈압화당뇨병등시결혈성졸중적위험인소,단타문부능부분해석졸중발병적원인.련생자、가계이급단기인유전성졸중연구현시,결혈성졸중구유명현적유전경향성.근년래,기인조학재결혈성졸중연구중취득료명현진전,병현시허다신적단핵감산다태성혹기인여결혈성졸중급기위험인소유관.연이,저사유전기인대결혈성졸중적공헌잉연태소,수요중복성연구진일보증실.
Ischemic stroke is one of the major diseases of causing adult disability and death.Age,sex,smoking,hypertension,and diabetes,etc.are the risk factors for ischemic stroke,but they can only partially explain the reasons of stroke onset.Twins,families,and single-gene genetic stroke studies have shown that ischemic stroke has obvious genetic predisposition.In recent years,genomics has made remarkable progress in ischemic stroke study and has shown that many new single nucleotide polymorphisms or genes are associated with ischemic stroke and its risk factors.However,the contribution of these genetic genes for ischemic stroke is still too small and the repetitive studies are needed for further confirmation.
