天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2013年
8期
766-768
,共3页
张颖%齐凤祥%张志广%江勇
張穎%齊鳳祥%張誌廣%江勇
장영%제봉상%장지엄%강용
螺杆菌,幽门%生长激素释放激素%胃炎,萎缩性%消化性溃疡%胃肿瘤%腺癌%胃蛋白酶原A%胃蛋白酶原C
螺桿菌,幽門%生長激素釋放激素%胃炎,萎縮性%消化性潰瘍%胃腫瘤%腺癌%胃蛋白酶原A%胃蛋白酶原C
라간균,유문%생장격소석방격소%위염,위축성%소화성궤양%위종류%선암%위단백매원A%위단백매원C
helicobacter pylori%growth hormone-releasing hormone%gastritis,atrophic%peptic ulcer%stomach neo-plasms%adenocarcinoma%pepsinogen A%pepsinogen C
目的探讨根除Hp治疗对生长激素调素（ghrelin）水平的影响及其临床意义。方法选取慢性浅表性胃炎（CSG）40例，慢性萎缩性胃炎（CAG）42例，消化性溃疡（PU）41例，胃腺癌（CA）17例，均为Hp阳性。Hp阴性正常对照组40例。仅对CAG、CSG及PU组行Hp根除治疗，应用酶联免疫法测定3组在Hp根除前后血清ghrelin和胃蛋白酶原（PG）的水平，分析PG与ghrelin的相关性。应用RT-PCR方法检测胃黏膜ghrelin的表达水平。结果与对照组（30.41±8.97）相比，PU组（35.42±9.87）ghrelin水平升高；CAG组（18.59±8.19）和CA组（18.33±6.88）ghrelin水平降低；而CSG组（26.08±9.14）与对照组差异无统计学意义。Hp根除后，CSG组的血清和胃黏膜的ghrelin水平均升高（P＜0.01）；PU组的血清和胃黏膜的ghrelin水平均下降（P＜0.01），而CAG组无明显变化（P＞0.05）。CSG、CAG和CA 3组患者血清PGⅠ/PGⅡ比值和ghrelin水平呈正相关（r=0.668，P＜0.01）。结论根除Hp治疗可以影响上消化道疾病患者的ghrelin水平，ghrelin水平和PGⅠ/PGⅡ相关。ghrelin可作为Hp相关上消化道疾病诊断和预后评估的检测指标之一。
目的探討根除Hp治療對生長激素調素（ghrelin）水平的影響及其臨床意義。方法選取慢性淺錶性胃炎（CSG）40例，慢性萎縮性胃炎（CAG）42例，消化性潰瘍（PU）41例，胃腺癌（CA）17例，均為Hp暘性。Hp陰性正常對照組40例。僅對CAG、CSG及PU組行Hp根除治療，應用酶聯免疫法測定3組在Hp根除前後血清ghrelin和胃蛋白酶原（PG）的水平，分析PG與ghrelin的相關性。應用RT-PCR方法檢測胃黏膜ghrelin的錶達水平。結果與對照組（30.41±8.97）相比，PU組（35.42±9.87）ghrelin水平升高；CAG組（18.59±8.19）和CA組（18.33±6.88）ghrelin水平降低；而CSG組（26.08±9.14）與對照組差異無統計學意義。Hp根除後，CSG組的血清和胃黏膜的ghrelin水平均升高（P＜0.01）；PU組的血清和胃黏膜的ghrelin水平均下降（P＜0.01），而CAG組無明顯變化（P＞0.05）。CSG、CAG和CA 3組患者血清PGⅠ/PGⅡ比值和ghrelin水平呈正相關（r=0.668，P＜0.01）。結論根除Hp治療可以影響上消化道疾病患者的ghrelin水平，ghrelin水平和PGⅠ/PGⅡ相關。ghrelin可作為Hp相關上消化道疾病診斷和預後評估的檢測指標之一。
목적탐토근제Hp치료대생장격소조소（ghrelin）수평적영향급기림상의의。방법선취만성천표성위염（CSG）40례，만성위축성위염（CAG）42례，소화성궤양（PU）41례，위선암（CA）17례，균위Hp양성。Hp음성정상대조조40례。부대CAG、CSG급PU조행Hp근제치료，응용매련면역법측정3조재Hp근제전후혈청ghrelin화위단백매원（PG）적수평，분석PG여ghrelin적상관성。응용RT-PCR방법검측위점막ghrelin적표체수평。결과여대조조（30.41±8.97）상비，PU조（35.42±9.87）ghrelin수평승고；CAG조（18.59±8.19）화CA조（18.33±6.88）ghrelin수평강저；이CSG조（26.08±9.14）여대조조차이무통계학의의。Hp근제후，CSG조적혈청화위점막적ghrelin수평균승고（P＜0.01）；PU조적혈청화위점막적ghrelin수평균하강（P＜0.01），이CAG조무명현변화（P＞0.05）。CSG、CAG화CA 3조환자혈청PGⅠ/PGⅡ비치화ghrelin수평정정상관（r=0.668，P＜0.01）。결론근제Hp치료가이영향상소화도질병환자적ghrelin수평，ghrelin수평화PGⅠ/PGⅡ상관。ghrelin가작위Hp상관상소화도질병진단화예후평고적검측지표지일。
Objective To investigate the impact and clinical significance of helicobacter pylori (Hp) elimination on ghrelin. Methods Forty patients with chronic superficial gastritis (CSG), 42 patients with chronic atrophic gastritis (CAG), 41 patients with peptic ulcer (PU) and 17 patients with gastric adenocarcinoma (CA) were included in this study. All of pa-tients in four groups were Hp-positive. Forty patients with Hp-negative were used as control. The Hp elimination were only performed in CAG,CSG and PU groups. The serum ghrelin and pepsinogen (PG) levels before and after Hp elimination were detected with ELISA assay in CSG, CAG and PU groups. The correlation between PG and glrelin was also detected. The ex-pression of ghrelin in gastric mucosa was detected by RT-PCR. Results Comparing with control group (30.41 ± 8.97), the ghrelin level was increased in PU group (35.42±9.87), but which were decreased in CAG group (18.59±8.19) and CA group (18.33±6.88). There was no significant difference in ghrelin level between CSG group (26.08±9.14) and control group. After Hp elimination, the serum and gastric mucosa ghrelin levels were significantly increased in CSG group (P<0.01), but both serum and gastric mucosa ghrelin levels were significantly decreased in PU group (P<0.01). And no significant difference in the level of ghrelin after Hp elimination in CAG group (P>0.05). A positive correlation was found between serum PGⅠ/PGⅡand serum ghrelin level in CSG, CAG and CA groups (r=0.668,P<0.01). Conclusion Hp elimination has an impact on ghrelin level in patients with upper gastrointestinal diseases. The changes of ghrelin level related to PGⅠ/PGⅡ. Ghrelin can be used as one of the indexes of diagnostic and prognostic evaluation in Hp related upper gastrointestinal diseases.
