CAJ | 학술논문

　　目的：观察参松养心胶囊对室性早搏患者心电图、心率变异性及血液流变学的影响。方法：60例随机分为治疗组及对照组，治疗组在常规治疗原发病的基础上口服倍他乐克和参松养心胶囊，对照组在常规治疗原发病的基础上口服倍他乐克。观察用药前后患者动态心电图，心率变异性及血液流变学变化。结果：4周后治疗组心电图改善总有效率为80.0%，对照组心电图改善总有效率为63.3%。两组比较差异有统计学意义（P<0.05）。治疗组治疗后心率变异性及血液流变学改善显著（P<0.05），对照组治疗后心率变异性改善有统计学意义（P<0.05），而血液流变学改变无统计学意义（P>0.05）；但治疗组心率变异性及血液流变学改善优于对照组(P<0.05)。结论：参松养心胶囊除通过多离子通道发挥抗心律失常作用外，同时可通过调节迷走神经，改善血液流变学等多途径发挥抗心律失常作用。
　　목적：관찰삼송양심효낭대실성조박환자심전도、심솔변이성급혈액류변학적영향。방법：60례수궤분위치료조급대조조，치료조재상규치료원발병적기출상구복배타악극화삼송양심효낭，대조조재상규치료원발병적기출상구복배타악극。관찰용약전후환자동태심전도，심솔변이성급혈액류변학변화。결과：4주후치료조심전도개선총유효솔위80.0%，대조조심전도개선총유효솔위63.3%。량조비교차이유통계학의의（P<0.05）。치료조치료후심솔변이성급혈액류변학개선현저（P<0.05），대조조치료후심솔변이성개선유통계학의의（P<0.05），이혈액류변학개변무통계학의의（P>0.05）；단치료조심솔변이성급혈액류변학개선우우대조조(P<0.05)。결론：삼송양심효낭제통과다리자통도발휘항심률실상작용외，동시가통과조절미주신경，개선혈액류변학등다도경발휘항심률실상작용。
Objective: To observe the effect of shensong yangxin capsule to the dynamic electrocardiogram, heart rate variability and hemorheology of the patients with ventricular premature beat. And discuss the possible mechanism of action. Methods: 60 cases of ventricular premature beat patients were randomly divided into treatment group and control group. Treatment group on the basis of conventional treatment of primary disease were given oral metoprolol and shensong yangxin capsule, while the control group were only given oral metoprolol on the basis of conventional treatment of primary disease. To observe the changes of patients’ dynamic electrocardiogram, heart rate variability and hemorheology before and after medication. Results: after 4 weeks, the total effective rates of improvement of the 2 groups’ electrocardiograms were 80.0% and 63.3% respectively. There were significant difference between the 2 groups. The heart rate variability and hemorheology of treatment group were improved significantly (P<0.05); The heart rate variability of control group were also improved significantly (P<0.05), but the hemorheology were not improved(P>0.05). The improvement of the heart rate variability and hemorheology of the treatment group were better than the control group(P<0.05). Conclusion: shensong yangxin capsule play the role of anti-arrhythmic, in addition to regulate the multiple ion channels, and adjust the vagus nerve, improve blood rheology and other ways.