CAJ | 학술논문

　　目的探讨不同剂量白酒对大鼠内皮细胞微颗粒水平的影响。方法60只雄性SD大鼠随机分成4组：白酒大剂量组（A组）、中剂量组（B组）、小剂量组（C组）和对照组（D组）,每组15只。白酒灌胃8周，采用流式细胞术检测各组大鼠血浆中CD31+/CD42-内皮微颗粒的水平，并比较其与白酒剂量的关系。结果与D组相比，A、B组大鼠血浆内皮细胞微颗粒水平显著升高（P<0.05），C组改变不明显（P>0.05）。结论大、中剂量白酒灌胃对大鼠血管内皮细胞功能有损害作用，呈明显的量效关系；小剂量白酒灌胃对大鼠血管内皮细胞功能无损害作用，是否有保护作用仍需进一步研究。
　　목적탐토불동제량백주대대서내피세포미과립수평적영향。방법60지웅성SD대서수궤분성4조：백주대제량조（A조）、중제량조（B조）、소제량조（C조）화대조조（D조）,매조15지。백주관위8주，채용류식세포술검측각조대서혈장중CD31+/CD42-내피미과립적수평，병비교기여백주제량적관계。결과여D조상비，A、B조대서혈장내피세포미과립수평현저승고（P<0.05），C조개변불명현（P>0.05）。결론대、중제량백주관위대대서혈관내피세포공능유손해작용，정명현적량효관계；소제량백주관위대대서혈관내피세포공능무손해작용，시부유보호작용잉수진일보연구。
Objective To discuss the impacts of different doses of alcohol on the level of microparticles (EMPs) of rat endothelial cells. Methods Sixty male SD rats were randomly allocated into four groups:high dose group (group A), me-dium dose group (group B), low dose group (group C) and the blank contrast group (group D). There were15 rats in each group. Rats were fed alcohol for 8 weeks. Flow cytometer was used to measure the level of circulating CD31+/CD42-EMPs in four groups, and which was compared with the alcohol dosage. Results Compared with group D, the level of circulating EMPs was significantly increased in group A and B (P<0.05). There was no significant change in the level of circulating EMPs in group C (P>0.05). Conclusion The moderate and high doses of alcohol are harmful to the function of vascular en-dothelial cells in rats, which show a significant dose-effect relationship. The low dose of alcohol shows no effect on the func-tion of vascular endothelial cells in rats. The protective effect of alcohol needs further investigation.