CAJ | 학술논문

　　目的研究PTEN、p21基因在哈萨克族食管癌中的表达。方法采用RT-PCR法检测PTEN、p21基因在48例哈萨克族食管癌组织及远端无癌组织中的表达，并分析其表达与肿瘤分化、TNM分期、临床分期、淋巴结转移的关系。结果 PTEN基因在癌组织和远端无癌组织中的表达阳性率分别为75%、45.8%，癌组织高于远端无癌组织（χ2=8.537，P＜0.05）；p21基因在癌组织和远端无癌组织中表达的阳性率分别为95.8%、97.9%，差异无统计学意义（χ2=0.344，P＞0.05）。PTEN和p21表达与食管癌分化程度、不同浸润深度及有无淋巴结转移均无相关性。结论PTEN、p21基因可能均不是哈萨克族食管癌的主要致病基因。
　　목적연구PTEN、p21기인재합살극족식관암중적표체。방법채용RT-PCR법검측PTEN、p21기인재48례합살극족식관암조직급원단무암조직중적표체，병분석기표체여종류분화、TNM분기、림상분기、림파결전이적관계。결과 PTEN기인재암조직화원단무암조직중적표체양성솔분별위75%、45.8%，암조직고우원단무암조직（χ2=8.537，P＜0.05）；p21기인재암조직화원단무암조직중표체적양성솔분별위95.8%、97.9%，차이무통계학의의（χ2=0.344，P＞0.05）。PTEN화p21표체여식관암분화정도、불동침윤심도급유무림파결전이균무상관성。결론PTEN、p21기인가능균불시합살극족식관암적주요치병기인。
Objective To investigate the expressions of PTEN and p21 genes in Hazak patients with esophageal can-cer. Methods The expressions of PTEN and p21 genes were detected by RT-PCR in 48 samples (cancer tissues and nor-mal tissues) of patients with esophageal cancer. The relationship between the expressions of PTEN and p21 genes, tumor dif-ferentiation, TNM stage, clinical phase and lymph node metastasis were analyzed. Results The positive rates of PTEN gene were 75%and 45.8%in cancer and distant normal tissues. The expression of PTEN was significantly higher in cancer tis-sues than that of distant normal tissues (χ2=8.537,P<0.05). The positive rates of p21 gene were 95.8%and 97.9%in cancer and distant normal tissues, and no significant difference between them (χ2=0.344,P>0.05). There was no correlation be-tween expressions of PTEN and p21and the tumor differentiation, the depth of invasion and lymph node metastasis in esopha-geal cancer. Conclusion PTEN and p21 genes are not the primary genes for the carcinogenesis of esophageal cancer in Hazak.