CAJ | 학술논문

　　目的：研究4-羟基苯并恶唑-2-酮（4-hydroxy-2-benzoxazolone ，HBOA）对四氯化碳（carbon tetrachloride ，CCl4）所致小鼠急性肝损伤的保护作用，并探讨其作用机制。方法：84只KM小鼠分组，造模，给药，采样，检测。结果：和模型组比较，中、高剂量HBOA能降低小鼠血清AST、ALT水平和肝组织MDA含量，升高肝组织SOD和GSH含量（P＜0．05，P＜0．01），同时能减轻肝细胞损伤程度（P＜0．01）。结论：HBOA对CCl4诱导的小鼠急性肝损伤有一定的保护作用，其作用机制可能与清除自由基，抑制脂质过氧化有关。
　　목적：연구4-간기분병악서-2-동（4-hydroxy-2-benzoxazolone ，HBOA）대사록화탄（carbon tetrachloride ，CCl4）소치소서급성간손상적보호작용，병탐토기작용궤제。방법：84지KM소서분조，조모，급약，채양，검측。결과：화모형조비교，중、고제량HBOA능강저소서혈청AST、ALT수평화간조직MDA함량，승고간조직SOD화GSH함량（P＜0．05，P＜0．01），동시능감경간세포손상정도（P＜0．01）。결론：HBOA대CCl4유도적소서급성간손상유일정적보호작용，기작용궤제가능여청제자유기，억제지질과양화유관。
Objective :The aim of this study was to investigate the protective effects of 4-hydroxy-2-benzoxazolone (HBOA) on carbon tetrachloride (CCl4 )-induced liver injury as well as the possible mechanisms involved in this pro-tection in mice .Methods :84 KM mice were randomly divided into seven equal groups ,then molding ,injection ,collec-ting the sample and analysis .Results:Compared with the model control group ,the high dose and middle dose of HBOA and positive control group ,the activities of AST and ALT in serum were decreased significantly (P< 0 .05 or P<0.01) .The levels of SOD and GSH in liver were increased significantly (P< 0 .05 or P< 0 .01) ,and MDA was de-creased significantly (P<0 .01) .And the degree of hepatic injury in high dose and middle dose HBOA groups and posi-tive control group could be lessened (P<0 .05 or P<0 .01) .Conclusion:The results show that HBOA can be proposed to protect the liver against CCl4-induced oxidative damage in mice ,and the hepatoprotective effect may be related with its antioxidant and free radical scavenger effects .