CAJ | 학술논문

背景：复方中药是由多种矿物植物动物等物质组成的复方药物，在治疗骨代谢疾病方面，能通过多途径，多靶点发挥综合治疗作用。 　　目的：研究复方中药对成骨细胞增殖及骨密度的影响，探讨复方中药对骨质疏松症的药理作用。 　　方法：回顾性分析以往经实验研究证实的某些复方中药对骨质疏松症动物模型成骨细胞增殖分化及骨密度的影响，分析影响复方中药促进骨形成的因素，通过对成骨细胞体外培养方法进行筛选，找出促进细胞增殖分化、提高骨密度的药物适宜剂量，与化学药物结果进行对照研究。 　　结果与结论：复方中药能够促进成骨细胞增殖分化、提高骨密度，在治疗骨质疏松症方面具有标本兼治、毒副作用小等优点，但复方中药在改善骨密度水平方面不及化学药物，并且应通过长期、大样本的临床研究，降低骨质疏松性骨折风险的干预作用。
　　배경：복방중약시유다충광물식물동물등물질조성적복방약물，재치료골대사질병방면，능통과다도경，다파점발휘종합치료작용。 　　목적：연구복방중약대성골세포증식급골밀도적영향，탐토복방중약대골질소송증적약리작용。 　　방법：회고성분석이왕경실험연구증실적모사복방중약대골질소송증동물모형성골세포증식분화급골밀도적영향，분석영향복방중약촉진골형성적인소，통과대성골세포체외배양방법진행사선，조출촉진세포증식분화、제고골밀도적약물괄의제량，여화학약물결과진행대조연구。 　　결과여결론：복방중약능구촉진성골세포증식분화、제고골밀도，재치료골질소송증방면구유표본겸치、독부작용소등우점，단복방중약재개선골밀도수평방면불급화학약물，병차응통과장기、대양본적림상연구，강저골질소송성골절풍험적간예작용。
BACKGROUND:Compound Chinese medicine is a kind of compound drugs with the combination of minerals, plants and animals, which play the multi-target integrated treatment effects in the treatment of bone metabolic disease through various methods. OBJECTIVE:To research the effect of compound traditional Chinese medicine on the proliferation and bone mineral density of osteoblasts, and to explore the pharmacological effect of compound traditional Chinese medicine in the treatment of osteoporosis. METHODS: A retrospective analysis was performed to analyze the effect of some compound traditional Chinese medicines on the proliferation and bone mineral density of osteoblasts that identified in the previous studies, in order to analyze the factors of compound traditional Chinese medicines that can promote the bone formation. The appropriate dose of the drugs that can promote cel proliferation and differentiation and improve the bone mineral density was screened out through the in vitro culture of osteoblasts, and then compared with the results of chemical medicines. RESULTS AND CONCLUSION:Compound traditional Chinese medicines can promote the proliferation and differentiation of osteoblasts and improve the bone mineral density, and have the advantages of ful treatment and less side effect in the treatment of osteoporosis. But the effect of compound traditional Chinese medicines in improving the bone mineral density is less than the chemical drugs. The long-term and large-sample clinical studies should be performed to decrease the risk of osteoporotic fracture.