CAJ | 학술논문

背景：目前常用的椎间融合方法较多，有自体骨块、同种异体骨及钛合金为主的腰椎后路椎间融合器等方法，但各有其优缺点。 　　目的：观察纳米羟基磷灰石/聚酰胺66复合生物活性椎间融合器用于腰椎后路椎间融合治疗腰椎疾患的临床疗效。 　　方法：回顾性分析2010年7月至2011年12月赣南医学院第一附属医院骨科收治的行腰椎后路椎间融合患者16例，均置入纳米羟基磷灰石/聚酰胺66复合生物活性椎间融合器。 　　结果与结论：所有患者随访10-24个月，腰痛均明显减轻，末次随访时腰痛疼痛目测类比评分、腰椎JOA评分及Oswestry功能障碍指数均较治疗前明显改善(P <0.05)。随访过程中均未发现内固定出现松动、断钉等情况；所有患者末次随访时均获得骨性融合，未见纳米羟基磷灰石/聚酰胺66复合生物活性椎间融合器移位及下沉。表明纳米羟基磷灰石/聚酰胺66复合生物活性椎间融合器用于腰椎后路椎间融合治疗能够重建腰椎稳定性，提供置入后的即刻稳定性，具有良好的生物学性能。
　　배경：목전상용적추간융합방법교다，유자체골괴、동충이체골급태합금위주적요추후로추간융합기등방법，단각유기우결점。 　　목적：관찰납미간기린회석/취선알66복합생물활성추간융합기용우요추후로추간융합치료요추질환적림상료효。 　　방법：회고성분석2010년7월지2011년12월공남의학원제일부속의원골과수치적행요추후로추간융합환자16례，균치입납미간기린회석/취선알66복합생물활성추간융합기。 　　결과여결론：소유환자수방10-24개월，요통균명현감경，말차수방시요통동통목측류비평분、요추JOA평분급Oswestry공능장애지수균교치료전명현개선(P <0.05)。수방과정중균미발현내고정출현송동、단정등정황；소유환자말차수방시균획득골성융합，미견납미간기린회석/취선알66복합생물활성추간융합기이위급하침。표명납미간기린회석/취선알66복합생물활성추간융합기용우요추후로추간융합치료능구중건요추은정성，제공치입후적즉각은정성，구유량호적생물학성능。
BACKGROUND:There are various commonly used interbody fusion methods, such as autologous bone, al ograft bone and titanium-based posterior lumbar interbody fusion, and each method has its own advantages and disadvantages. OBJECTIVE:To observe the clinical efficacy of a bioactive nano-hydroxyapatite/polyamide 66 fusion cage in posterior lumbar interbody fusion for the treatment of lumbar disease. METHODS:A retrospective case analysis was conducted on 16 cases treated with posterior lumbar interbody fusion at the Department of Orthopedic, the First Affiliated Hospital of Gannan Medical University from July 2010 to December 2011, and al the patients were implanted with nano-hydroxyapatite/polyamide 66 biological activity fusion cage. RESULTS AND CONCLUSION:Al the patients were fol owed-up for 10-24 months, and the lumbar pain was significant improved, the lumbar visual analogue score, lumbar Japanese Orthopaedic Association score and Oswestry disability index score were significantly improved during the final fol ow-up period (P<0.05). No internal fixation loosing or broken observed in al the patients during final fol ow-up, and al the patients obtained bone fusion without nano-hydroxyapatite/polyamide 66 fusion cage displacement or subsidence. The results indicate that nano-hydroxyapatite/polyamide 66 fusion cage for the treatment of posterior lumbar interbody fusion can reconstruct the lumbar stability and provide immediate stability after implantation, and has good biological activity.