中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
35期
6333-6338
,共6页
骨关节植入物%骨与关节综述%骨不连%生物力学%电刺激%低强度脉冲超声波%体外冲击波%交锁髓内钉%外固定支架%骨移植%省级基金
骨關節植入物%骨與關節綜述%骨不連%生物力學%電刺激%低彊度脈遲超聲波%體外遲擊波%交鎖髓內釘%外固定支架%骨移植%省級基金
골관절식입물%골여관절종술%골불련%생물역학%전자격%저강도맥충초성파%체외충격파%교쇄수내정%외고정지가%골이식%성급기금
bone and joint implants%review of bone and joint%nonunion%biomechanics%electrical stimulation%low-intensity pulsed ultrasound%extracorporeal shock wave%intramedul ary nail%external fixation%bone graft%provincial grants-supported paper
背景：骨不连是骨折晚期常见的临床问题，数十年来，在各种新式内外固定材料、普及的显微外科技术、创新的植骨材料，尤其是分子生物学技术的全面帮助下，骨不连的治疗取得了突破性进展。<br> 目的：总结骨不连治疗的研究进展，为以后更好地治疗骨不连提供技术理论和方法选择。<br> 方法：由第一作者运用计算机检索系统检索1990年1月至2013年5月发表的有关骨不连原因及治疗方法的文献，以“fracture nonunion，treatment，progress”或“骨不连，治疗方法，进展”为检索词。同一领域则选择近期发表或者发表在权威杂志的文章。<br> 结果与结论：排除重复性研究及时间跨度大的文献，从检索结果中共选择了48篇文章进一步分析。骨不连治疗手段主要有两种：非手术方式和手术方式，目前临床上以手术方式为主且高效。骨折愈合是多环节参与的复杂过程，一旦骨不连发生，应具体问题具体分析，根据患者的实际情况采取个体化治疗原则，重视软组织的保护，必要时联合运用多种手术及非手术方法，才能取得满意的疗效。
揹景：骨不連是骨摺晚期常見的臨床問題，數十年來，在各種新式內外固定材料、普及的顯微外科技術、創新的植骨材料，尤其是分子生物學技術的全麵幫助下，骨不連的治療取得瞭突破性進展。<br> 目的：總結骨不連治療的研究進展，為以後更好地治療骨不連提供技術理論和方法選擇。<br> 方法：由第一作者運用計算機檢索繫統檢索1990年1月至2013年5月髮錶的有關骨不連原因及治療方法的文獻，以“fracture nonunion，treatment，progress”或“骨不連，治療方法，進展”為檢索詞。同一領域則選擇近期髮錶或者髮錶在權威雜誌的文章。<br> 結果與結論：排除重複性研究及時間跨度大的文獻，從檢索結果中共選擇瞭48篇文章進一步分析。骨不連治療手段主要有兩種：非手術方式和手術方式，目前臨床上以手術方式為主且高效。骨摺愈閤是多環節參與的複雜過程，一旦骨不連髮生，應具體問題具體分析，根據患者的實際情況採取箇體化治療原則，重視軟組織的保護，必要時聯閤運用多種手術及非手術方法，纔能取得滿意的療效。
배경：골불련시골절만기상견적림상문제，수십년래，재각충신식내외고정재료、보급적현미외과기술、창신적식골재료，우기시분자생물학기술적전면방조하，골불련적치료취득료돌파성진전。<br> 목적：총결골불련치료적연구진전，위이후경호지치료골불련제공기술이론화방법선택。<br> 방법：유제일작자운용계산궤검색계통검색1990년1월지2013년5월발표적유관골불련원인급치료방법적문헌，이“fracture nonunion，treatment，progress”혹“골불련，치료방법，진전”위검색사。동일영역칙선택근기발표혹자발표재권위잡지적문장。<br> 결과여결론：배제중복성연구급시간과도대적문헌，종검색결과중공선택료48편문장진일보분석。골불련치료수단주요유량충：비수술방식화수술방식，목전림상상이수술방식위주차고효。골절유합시다배절삼여적복잡과정，일단골불련발생，응구체문제구체분석，근거환자적실제정황채취개체화치료원칙，중시연조직적보호，필요시연합운용다충수술급비수술방법，재능취득만의적료효。
BACKGROUND:Nonunion is a common clinical problem of bone fracture. For decades, with the help of <br> internal/external fixation materials, popularization of microsurgical technique, innovation of bone graft materials, especial y molecular biology techniques, breakthrough progress has been made in the treatment of nonunion. OBJECTIVE:To summarize the research progress of treatment in nonunion and to provide better technology theory and choices of method for the treatment of nonunion in future. <br> METHODS:The PubMed database and CNKI database were retrieved by the first author for the articles related to reason and treatment method of nonunion published from January 1990 to May 2013. The key words were <br> “fracture nonunion, treatment, progress”. For the articles in the same field, those published recently or in authorized journals were selected. <br> RESULTS AND CONCLUSION:The repetitive and old articles were eliminated, and final y 48 articles were selected for further analysis. At present, two methods can be used in the treatment of nonunion, including <br> nonsurgical method and surgical method, the surgical method is utilized more frequently and more efficiency in clinic. Fracture healing is the complex process involving various aspects, and once the nonunion occurred, <br> different patients should be treated with different methods, and the combination of various surgical and <br> nonsurgical methods can be used if necessary to obtain satisfactory effect. But al the treatment methods should pay attention to soft tissue protection.
