CAJ | 학술논문

背景：目前研究腰椎间盘退变的磁共振分子影像主要有T2 mapping和T1ρ两种技术。目的：探讨1.5 TMR用于新西兰大白兔腰椎间盘T2 mapping成像的可行性。 　　方法：采用1.5 TMR设备进行新西兰大白兔腰椎间盘磁共振T2 mapping成像，利用后处理工作站测量感兴趣区的腰椎间盘组织T2值。 　　结果与结论：在1.5 T MR设备上可获得满意的3月龄新西兰大白兔腰椎间盘矢状位与冠状位T2-map图像。Pfirrmann Ⅰ级的L4/5、L5/6及L6/7椎间盘中央部髓核组织T2值分别为(104.6±14.0) ms，(109.1±13.8) ms和(109.5±15.1) ms；腹侧纤维环T2值分别为(82.1±9.5) ms，(80.4±11.2) ms和(79.9±10.6) ms；背侧纤维环T2值分别为(85.8±11.9) ms，(85.1±12.1) ms和(85.3±9.3) ms。在Pfirrmann Ⅰ级的L4/5、L5/6及L6/7三组间椎间盘髓核组织、腹侧纤维环和背侧纤维环的T2值差异均无显著性意义(P >0.05)。然而同一椎间盘内髓核组织T2值高于纤维环T2值(P <0.01)，而腹侧与背侧纤维环之间的T2值差异无显著性意义(P >0.05)。可见在1.5 T MR设备上获得的兔腰椎间盘T2值可用于定量评估椎间盘组织信号。
　　배경：목전연구요추간반퇴변적자공진분자영상주요유T2 mapping화T1ρ량충기술。목적：탐토1.5 TMR용우신서란대백토요추간반T2 mapping성상적가행성。 　　방법：채용1.5 TMR설비진행신서란대백토요추간반자공진T2 mapping성상，이용후처리공작참측량감흥취구적요추간반조직T2치。 　　결과여결론：재1.5 T MR설비상가획득만의적3월령신서란대백토요추간반시상위여관상위T2-map도상。Pfirrmann Ⅰ급적L4/5、L5/6급L6/7추간반중앙부수핵조직T2치분별위(104.6±14.0) ms，(109.1±13.8) ms화(109.5±15.1) ms；복측섬유배T2치분별위(82.1±9.5) ms，(80.4±11.2) ms화(79.9±10.6) ms；배측섬유배T2치분별위(85.8±11.9) ms，(85.1±12.1) ms화(85.3±9.3) ms。재Pfirrmann Ⅰ급적L4/5、L5/6급L6/7삼조간추간반수핵조직、복측섬유배화배측섬유배적T2치차이균무현저성의의(P >0.05)。연이동일추간반내수핵조직T2치고우섬유배T2치(P <0.01)，이복측여배측섬유배지간적T2치차이무현저성의의(P >0.05)。가견재1.5 T MR설비상획득적토요추간반T2치가용우정량평고추간반조직신호。
BACKGROUND:The magnetic resonance molecular imaging used in the research of lumbar disc degeneration includes T2 mapping and T1ρtechnologies at present. OBJECTIVE:To evaluate the feasibility of 1.5 T MR equipment on T2 mapping of New Zealand white rabbits lumbar disc. METHODS:T2 mapping images of New Zealand white rabbit lumbar discs were obtained on 1.5 T MR equipment. The regions of interest T2 values of lumbar discs were measured with post-processing workstation. RESULTS AND CONCLUSION:Sagittal and coronal T2 maps of 3-month rabbit discs were obtained satisfactorily on 1.5 T MR equipment. The regions of interest T2 values of nucleus pulposus in L 4/5 , L 5/6 and L 6/7 discs were (104.6±14.0) ms, (109.1±13.8) ms and (109.5±15.1) ms respectively at Pfirrmann regions of interest T2 values of anterior annulus fibrosus in L 4/5 , L 5/6 and L 6/7 discs were (82.1±9.5) ms, (80.4± 11.2) ms and (79.9±10.6) ms respectively, and T2 values of posterior annulus fibrosus in L 4/5 , L 5/6 and L 6/7 discs were (85.8±11.9) ms, (85.1±12.1) ms and (85.3±9.3) ms respectively. There were no significant differences in T2 values of nucleus pulposus, anterior annulus fibrosus and posterior annulus fibrosus in L 4/5 , L 5/6 and L 6/7 discs at PfirrmannⅠP>g 0ra.0d5e).( However, the T2 values of nucleus pulposus were higher than those of annulus fibrosus in the same discs (P<0.01), and there were no significant differences in T2 values between the anterior and posterior annulus fibrosus (P>0.05). The T2 values of rabbit lumbar discs obtained on 1.5 T MR equipment can be used for quantitative assessment of intervertebral disc signal.