CAJ | 학술논문

目的探讨亚临床甲状腺功能减退与2型糖尿病患者无症状心肌缺血之间的关系.方法回顾性分析399例成功行冠状动脉CT血管成像检查无心肌缺血症状的、无已知甲状腺疾病的2型糖尿病患者的临床资料,根据是否合并亚临床甲状腺功能减退分为亚临床甲状腺功能减退组(17例)与甲状腺功能正常组(382例),分析两组患者的临床资料、实验室检查结果及冠状动脉CT血管成像检查结果.结果 2型糖尿病患者中亚临床甲状腺功能减退的发生率为4.3％(17/399),亚临床甲状腺功能减退组中男性比例及吸烟比例均低于甲状腺功能正常组,差异有统计学意义(3/17比194/382,P=0.007；2/17比136/382,P=0.043).亚临床甲状腺功能减退组无症状心肌缺血发生5例,甲状腺功能正常组为130例,两组比较差异无统计学意义(P=0.694).两组年龄、糖尿病病程、糖化血红蛋白、低密度脂蛋白胆固醇比较差异也无统计学意义(P＞0.05).结论亚临床甲状腺功能减退不是2型糖尿病患者无症状心肌缺血的危险因素.
목적 탐토아림상갑상선공능감퇴여2형당뇨병환자무증상심기결혈지간적관계.방법 회고성분석399례성공행관상동맥CT혈관성상검사무심기결혈증상적、무이지갑상선질병적2형당뇨병환자적림상자료,근거시부합병아림상갑상선공능감퇴분위아림상갑상선공능감퇴조(17례)여갑상선공능정상조(382례),분석량조환자적림상자료、실험실검사결과급관상동맥CT혈관성상검사결과.결과 2형당뇨병환자중아림상갑상선공능감퇴적발생솔위4.3％(17/399),아림상갑상선공능감퇴조중남성비례급흡연비례균저우갑상선공능정상조,차이유통계학의의(3/17비194/382,P=0.007；2/17비136/382,P=0.043).아림상갑상선공능감퇴조무증상심기결혈발생5례,갑상선공능정상조위130례,량조비교차이무통계학의의(P=0.694).량조년령、당뇨병병정、당화혈홍단백、저밀도지단백담고순비교차이야무통계학의의(P＞0.05).결론 아림상갑상선공능감퇴불시2형당뇨병환자무증상심기결혈적위험인소.
Objective To determine the relationship between subclinical hypothyroidism and asymptomatic myocardial ischemia in type 2 diabetes mellitus.Methods All of 399 asymptomatic subjects who underwent coronary CT angiography with type 2 diabetes mellitus but without thyroid disease were enrolled retrospectively.Totally patients were divided into subclinical hypothyroidism group (17 patients,type 2 diabetes mellitus with subclinical hypothyroidism) and euthyroid group(382 patients,type 2 diabetes mellitus with normal thyroid function).Results The incidence of subclinical hypothyroidism in type 2 diabetes mellitus was 4.3％(17/399).The ratio of male and smoking in subclinical hypothyroidism group was significantly lower than that in euthyroid group (3/17 vs.194/382,P =0.007;2/17 vs.136/382,P =0.043).The incidence of asymptomatic myocardial ischemia in subclinical hypothyroidism group was 5 cases and in euthyroid group was 130 cases,and there was no significant difference(P=0.694).The age,course of type 2 diabetes mellitus,level of glycosylated hemoglobin and low density lipoprotein cholesterol between two groups had no significant difference(P＞ 0.05).Conclusion Subclinical hypothyroidism is not an independent risk factor for asymptomatic myocardial ischemia in type 2 diabetes mellitus.