CAJ | 학술논문

目的：探讨HIV感染者外周血T淋巴细胞亚群数量及功能与疾病进展的关系。方法通过流式细胞仪法检测健康志愿者与HIV感染不同程度患者的外周血T淋巴细胞亚群CD 3+、CD 4+、CD 8+T细胞数量及功能，比较不同HIV感染者T细胞亚群数量的差异。结果 LTNP组、HIV组与AIDS组的CD 3+、CD 4+数量均显著降低，CD 4+/CD 8+倒置明显，且均与对照组比较存在显著性差异（P<0.01），且随着HIV感染的加重，CD 4+数量显著降低，CD 4+/CD 8+比值倒置愈加显著，CD 8+及CD 3+数量降低。结论 HIV感染后，CD 4+T细胞数量显著降低，CD 4+/CD 8+比值也随之降低，且随着疾病进展，变化显著，提示T细胞亚群数量及功能变化可能对疾病进展情况具有重要临床指示作用。
목적：탐토HIV감염자외주혈T림파세포아군수량급공능여질병진전적관계。방법통과류식세포의법검측건강지원자여HIV감염불동정도환자적외주혈T림파세포아군CD 3+、CD 4+、CD 8+T세포수량급공능，비교불동HIV감염자T세포아군수량적차이。결과 LTNP조、HIV조여AIDS조적CD 3+、CD 4+수량균현저강저，CD 4+/CD 8+도치명현，차균여대조조비교존재현저성차이（P<0.01），차수착HIV감염적가중，CD 4+수량현저강저，CD 4+/CD 8+비치도치유가현저，CD 8+급CD 3+수량강저。결론 HIV감염후，CD 4+T세포수량현저강저，CD 4+/CD 8+비치야수지강저，차수착질병진전，변화현저，제시T세포아군수량급공능변화가능대질병진전정황구유중요림상지시작용。
Objective To investigate the relationship between the peripheral blood T-cell subgroups counts of the HIV infection patients and the progression of the disease. Methods To detect the peripheral blood CD 3+,CD 4+, CD 8+T cells counts of the healthy volunteers and the HIV infection patients in different stages by lfow cytometry method (FCM) , and compare the difference of the T-cell subgroups counts among the HIV infection patients in different stages. Results The CD 3+,CD 4+T cells counts of the long-term nonprogressors group,the HIV group and the AIDS group declined significantly,as well as the obvious inversion of the CD 4+/CD 8+,and they had significant difference compared with the control group.With the progression of the HIV infection , CD 4+ T cells counts declined signiifcantly ,and the inversion of the CD 4+/CD 8+ became more signiifcant ,also the reduce of the CD 3+, CD 8+T cells counts. Conclusion After the HIV infection ,the CD 4+ T cells counts declined signiifcantly ,as well as the ratio of CD 4+/CD 8+. And with the progression of the disease ,the change became signiifcant ,which prompting that the change of T-cell subgroups counts and function may have important clinical indication for the progress of the disease.