CAJ | 학술논문

目的分析白内障术后妥布霉素地塞米松滴眼液滴眼引起药源性角膜损伤发生的相关因素.方法对白内障术后滴用妥布霉素地塞米松滴眼液者193例(197眼)进行临床回顾,其中24例(25眼)发生药源性角膜损伤,对引起药源性角膜损伤的相关因素进行分析.结果药源性角膜损伤以术后2～3周发生的最多;以浅层点状角膜上皮浑浊所占比例最高.按高血压、高血糖、高龄等相关因素分析,损伤组相关性明显高于无损伤组,差异有统计学意义(x2=7.90,P=0.01;x2=10.41,P=0.00x2=8.95,P=0.00);无损伤组术后视力及视力恢复时间明显好于药源性损伤组(x2=5.63,P=0.02;t=12.20,P=0.01).结论白内障术后应用妥布霉素地塞米松引起的药源性角膜损伤明显影响术后的视力恢复;高血压、糖尿病以及高龄因素与药源性角膜损伤有关,白内障术后需要重视药源性角膜损伤的发生,对于合并高血压、糖尿病以及老年患者需要加强观察,注意合理用药.
목적 분석백내장술후타포매소지새미송적안액적안인기약원성각막손상발생적상관인소.방법 대백내장술후적용타포매소지새미송적안액자193례(197안)진행림상회고,기중24례(25안)발생약원성각막손상,대인기약원성각막손상적상관인소진행분석.결과 약원성각막손상이술후2～3주발생적최다;이천층점상각막상피혼탁소점비례최고.안고혈압、고혈당、고령등상관인소분석,손상조상관성명현고우무손상조,차이유통계학의의(x2=7.90,P=0.01;x2=10.41,P=0.00x2=8.95,P=0.00);무손상조술후시력급시력회복시간명현호우약원성손상조(x2=5.63,P=0.02;t=12.20,P=0.01).결론 백내장술후응용타포매소지새미송인기적약원성각막손상명현영향술후적시력회복;고혈압、당뇨병이급고령인소여약원성각막손상유관,백내장술후수요중시약원성각막손상적발생,대우합병고혈압、당뇨병이급노년환자수요가강관찰,주의합리용약.
Objective To analyze the related factors of drug-induced corneal lesions after cataract surgery.Methods 197 eyes of 193 cases who used tobramycin dexamethasone eye drops after cataract surgery were enrolled in this retrospective study.Totally 25 eyes of 24 cases were diagnosed as drug-induced corneal lesions.The factors related to drug-induced corneal lesions were analyzed.Results Most druginduced corneal lesions were taken placed at 2 to 3 weeks after surgery and the main corneal lesion was superficial punctate corneal opacity.Hypertension,diabetes and aging were the most common risk factors which related to drug-induced corneal lesions (P ＜ 0.05).The relevance in lesion group was higher than that in normal group and the difference was statistically significant (x2 =7.90,P =0.01 ;x2 =10.41,P =0.00 ; x2 =8.95,P =0.00).The vision acuity and visual recovery time of normal group were better than that of lesion group (x2 =5.63,P =0.02; t =12.20,P =0.01).Conclusion After cataract surgery,need to be taken seriously for drug-induced corneal lesions which can harm postoperative visual acuity,especially for elderly patients and patients with hypertension or diabetes.