CAJ | 학술논문

目的探讨经皮椎体成形术(PVP)治疗新鲜骨质疏松性椎体压缩性骨折(OVCF)的临床疗效. 方法 2010年2月至201 1年l 1月对103例新鲜OVCF患者根据治疗方法不同分为PVP组(41例)和保守组(62例).两组患者术前一般资料比较差异均无统计学意义(P＞ 0.05),具有可比性.所有患者分别于治疗前、治疗后1、4、12、24、48周进行疼痛评分,随访并记录患者治疗后1年内再发椎体骨折的情况.比较两组患者术后疼痛缓解及再发椎体压缩性骨折的风险. 结果治疗后1、4、12周PVP组患者总疼痛缓解程度好于保守治疗组,差异均有统计学意义(P＜0.05).治疗后1、4、12周PVP组患者夜间休息疼痛缓解程度好于保守组,差异均有统计学意义(P＜0.05).治疗后1年PVP组和保守组分别观察到7例(18.4％,7/38)和12例(20.3％,12/59)患者再发胸腰椎压缩骨折,两组再发椎体骨折风险差异无统计学意义(Hazard Ratio=0.909,95％ CI:0.36～2.29,P=0.841).结论与保守治疗相比,PVP可明显降低OVCF患者的疼痛,且并不增加术后再发椎体骨折的风险.
목적 탐토경피추체성형술(PVP)치료신선골질소송성추체압축성골절(OVCF)적림상료효. 방법 2010년2월지201 1년l 1월대103례신선OVCF환자근거치료방법불동분위PVP조(41례)화보수조(62례).량조환자술전일반자료비교차이균무통계학의의(P＞ 0.05),구유가비성.소유환자분별우치료전、치료후1、4、12、24、48주진행동통평분,수방병기록환자치료후1년내재발추체골절적정황.비교량조환자술후동통완해급재발추체압축성골절적풍험. 결과 치료후1、4、12주PVP조환자총동통완해정도호우보수치료조,차이균유통계학의의(P＜0.05).치료후1、4、12주PVP조환자야간휴식동통완해정도호우보수조,차이균유통계학의의(P＜0.05).치료후1년PVP조화보수조분별관찰도7례(18.4％,7/38)화12례(20.3％,12/59)환자재발흉요추압축골절,량조재발추체골절풍험차이무통계학의의(Hazard Ratio=0.909,95％ CI:0.36～2.29,P=0.841).결론 여보수치료상비,PVP가명현강저OVCF환자적동통,차병불증가술후재발추체골절적풍험.
Objective To evaluate the clinical efficacy of percutaneous vertebroplasty (PVP) for patients with fresh osteoporotic vertebral compression fracture (OVCF).Methods From February 2010 to November 2011,103 patients with fresh OVCF were assigned to receive either PVP or conservative treatment according to their choice or the choice of surgeons.There were no significant differences between the 2 groups regarding general clinical data (P ＞ 0.05).The pain was scored at pre-treatment,1,4,12,24 and 48 weeks post-treatment in all the patients.The vertebral re-fractures were recorded in both groups at follow-ups.The 2 groups were compared in terms of postoperative pain relief and risk of re-fracture.Results The overall pain relief at 1,4 and 12 post-treatment in the PVP group was significantly greater than in the conservative treatment group (P ＜ 0.05).The pain relief at night at 1,4 and 12 post-treatment was significantly greater in the PVP group than in the conservative treatment group (P ＜ 0.05).At one year post-treatment,7 vertebral re-fractures were observed in the PVP group (18.4％,7/38) and 12 ones in the conservative treatment group (20.3％,12/59),with no significant difference between the 2 groups in the risk of re-fracture (Hazard ratio =0.909,95％ CI:O.36 ～ 2.29,P =0.841).Conclusion Compared with conservative treatment,PVP may significantly reduce the pain for patients with fresh OVCF but does not increase the risk of vertebral re-fracture.