重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
12期
1442-1444
,共3页
脑出血%早期康复%Fugl-Meyer评分%Barthel指数%内皮%干细胞%血管内皮生长因子
腦齣血%早期康複%Fugl-Meyer評分%Barthel指數%內皮%榦細胞%血管內皮生長因子
뇌출혈%조기강복%Fugl-Meyer평분%Barthel지수%내피%간세포%혈관내피생장인자
cerebral hemorrhage%early rehabilitation%Fugl-Meyer reassessment%Barthel index%endothelium%stem cells%vascular endothelial growth factor
目的：探讨早期康复治疗对小量脑出血患者功能恢复的作用及其可能机制。方法将133例脑出血患者随机分成常规治疗、非早期康复和早期康复3组，3组患者均常规使用内科药物治疗，早期康复组、非早期康复组分别于第2天和第14天进行康复治疗，比较患者治疗前与治疗4周后的Fugl-Meyer评分和Barthel指数，并检测治疗前、后患者血清中循环内皮祖细胞（EPCs）和血管内皮生长因子（VEGF）的变化。结果早期康复组患者治疗后 Fugl-Meyer评分和Barthel指数较常规治疗组、非早期康复组明显增高（P＜0．01），血清中EPCs和VEGF较常规治疗组显著升高（P＜0．01）。结论早期康复治疗能明显改善患者的肢体运动功能和日常生活能力，其机制可能与循环EPCs和VEGF增加有关。
目的：探討早期康複治療對小量腦齣血患者功能恢複的作用及其可能機製。方法將133例腦齣血患者隨機分成常規治療、非早期康複和早期康複3組，3組患者均常規使用內科藥物治療，早期康複組、非早期康複組分彆于第2天和第14天進行康複治療，比較患者治療前與治療4週後的Fugl-Meyer評分和Barthel指數，併檢測治療前、後患者血清中循環內皮祖細胞（EPCs）和血管內皮生長因子（VEGF）的變化。結果早期康複組患者治療後 Fugl-Meyer評分和Barthel指數較常規治療組、非早期康複組明顯增高（P＜0．01），血清中EPCs和VEGF較常規治療組顯著升高（P＜0．01）。結論早期康複治療能明顯改善患者的肢體運動功能和日常生活能力，其機製可能與循環EPCs和VEGF增加有關。
목적：탐토조기강복치료대소량뇌출혈환자공능회복적작용급기가능궤제。방법장133례뇌출혈환자수궤분성상규치료、비조기강복화조기강복3조，3조환자균상규사용내과약물치료，조기강복조、비조기강복조분별우제2천화제14천진행강복치료，비교환자치료전여치료4주후적Fugl-Meyer평분화Barthel지수，병검측치료전、후환자혈청중순배내피조세포（EPCs）화혈관내피생장인자（VEGF）적변화。결과조기강복조환자치료후 Fugl-Meyer평분화Barthel지수교상규치료조、비조기강복조명현증고（P＜0．01），혈청중EPCs화VEGF교상규치료조현저승고（P＜0．01）。결론조기강복치료능명현개선환자적지체운동공능화일상생활능력，기궤제가능여순배EPCs화VEGF증가유관。
Objective To investigate the effect of early rehabilitation treatment in the patients with small cerebral hemorrhage and its possible mechanisms .Methods 133 patients with cerebral hemorrhage were randomly divided into the routine treatment , non-early rehabilitation and early rehabilitation groups and given the routine drug treatment .The early rehabilitation group and the non-early rehabilitation group were additionally given the rehabilitative training after 2 d and 14 d respectively .The scores of Fugl-Meyer reassessment and the Barthel index were assessed before training and after 4-week training ,and the serum levels of circulat-ing endotheial progenitor cells(EPCs) and vascular endotheial cell growth factors(VEGF) were detected .Results Compared with the routine treatment group and the non-early rehabilitation group ,the scores of Fugl-Meyer reassessment and the Barthel index af-ter treatment in the early rehabilitation group were significantly increased (P< 0 .01) .The serum levels of circulating EPCs and VEGF in the early rehabilitation group were also significantly increased compared with the routine treatment group control (P<0 .01) .Conclusion Early rehabilitation treatment can obviously improve the limb movement function and the daily living ability in the patients with small cerebral hemorrhage ,its mechanisms may be involved with the increase of circulating EPCs and VEGF .
