现代仪器与医疗
現代儀器與醫療
현대의기여의료
Modern Instrument and Medical Treatment
2014年
3期
97-99
,共3页
血清同型半胱氨酸%高同型半胱氨酸血症%缺血性脑卒中
血清同型半胱氨痠%高同型半胱氨痠血癥%缺血性腦卒中
혈청동형반광안산%고동형반광안산혈증%결혈성뇌졸중
homocysteine levels in blood%the elevated plasma Hcy level%ischemic stroke
目的：探讨血清同型半胱氨酸（Hcy）含量与缺血性脑卒中患者病情严重程度的关系。方法：将580例缺血性脑卒中患者按照神经功能缺损程度（NIHSS）评分分为轻症组258例、中症组146例及重症组96例，比较三组患者Hcy含量及高同型半胱氨酸血症（HHcy）比例。对HHcy患者采取综合治疗措施10d后，比较治疗前后Hcy含量及美国国立卫生院神经功能缺损评分(NIHSS评分)结果。结果：由轻症组、中症组至重症组，三组Hcy水平及HHcy患者占比逐渐上升，组间差异具有统计学意义(P<0.05)；HHcy患者治疗10d后的NIHSS评分（9.83±6.17）及Hcy含量为（18.5±5.7）umol/L，显著低于治疗前的NIHSS评分（19.33±6.03）及Hcy的含量（37.2±5.8）umol/L，两组比较差异显著（P<0.01）。结论：Hcy含量与缺血性脑卒中患者病情严重程度密切相关，高Hcy患者的神经缺损程度高，治疗HHcy有助于改善缺血性脑卒中患者预后。
目的：探討血清同型半胱氨痠（Hcy）含量與缺血性腦卒中患者病情嚴重程度的關繫。方法：將580例缺血性腦卒中患者按照神經功能缺損程度（NIHSS）評分分為輕癥組258例、中癥組146例及重癥組96例，比較三組患者Hcy含量及高同型半胱氨痠血癥（HHcy）比例。對HHcy患者採取綜閤治療措施10d後，比較治療前後Hcy含量及美國國立衛生院神經功能缺損評分(NIHSS評分)結果。結果：由輕癥組、中癥組至重癥組，三組Hcy水平及HHcy患者佔比逐漸上升，組間差異具有統計學意義(P<0.05)；HHcy患者治療10d後的NIHSS評分（9.83±6.17）及Hcy含量為（18.5±5.7）umol/L，顯著低于治療前的NIHSS評分（19.33±6.03）及Hcy的含量（37.2±5.8）umol/L，兩組比較差異顯著（P<0.01）。結論：Hcy含量與缺血性腦卒中患者病情嚴重程度密切相關，高Hcy患者的神經缺損程度高，治療HHcy有助于改善缺血性腦卒中患者預後。
목적：탐토혈청동형반광안산（Hcy）함량여결혈성뇌졸중환자병정엄중정도적관계。방법：장580례결혈성뇌졸중환자안조신경공능결손정도（NIHSS）평분분위경증조258례、중증조146례급중증조96례，비교삼조환자Hcy함량급고동형반광안산혈증（HHcy）비례。대HHcy환자채취종합치료조시10d후，비교치료전후Hcy함량급미국국립위생원신경공능결손평분(NIHSS평분)결과。결과：유경증조、중증조지중증조，삼조Hcy수평급HHcy환자점비축점상승，조간차이구유통계학의의(P<0.05)；HHcy환자치료10d후적NIHSS평분（9.83±6.17）급Hcy함량위（18.5±5.7）umol/L，현저저우치료전적NIHSS평분（19.33±6.03）급Hcy적함량（37.2±5.8）umol/L，량조비교차이현저（P<0.01）。결론：Hcy함량여결혈성뇌졸중환자병정엄중정도밀절상관，고Hcy환자적신경결손정도고，치료HHcy유조우개선결혈성뇌졸중환자예후。
Object:To discuss the relationship between homocysteine levels in blood and severity of ischemic stroke.Method:We divide 580 cases of ischemic stroke patients in accordance with neurologic NIHSS score into mild group (258 cases), medium group(146 cases) and severe group (188cases). We compared the Hcy level and computed the proportion of the elevated plasma Hcy level in the three groups. After treating with comprehensive treatment lasting 10 days, the Hcy levels and NIHSS score of paitents with HHcy before and after treatment were compared.Result:The Hcy level and the rate of HHcy rase one by one in mild group, medium group and severe group,also P<0.05, the differences were statistically significant. After treating with comprehensive treatment lasting 10 days, he Hcy levels and NIHSS score of paitents with HHcy are(18.5±5.7)umol/L and(9.83±6.17),while they are(18.5±5.7)umol/L and(19.33±6.03)before treatment .The difference between two groups was signiifcant(P<0.01).Conclusion:The relationship between Hcy levels in blood and severity of ischemic stroke was closely related. The higher level of Hcy is, the severer state of illness is . After state of illness easing, the content fall down along with it. With the active treatment, the conditions of prognosis of paitents with HHcy can be better.
