CAJ | 학술논문

　　改进经皮给药系统的最常用方法是使用透皮促进剂，促透剂能可逆地减小药物透过皮肤的障碍。虽然化学促进剂的促透作用已经得到了广泛研究，但它们的定量构效关系研究报道还不多见。本文用逐步多元线性回归分析，建立了16种烷醇促透剂的促透能力与其理化参数之间的相关方程式。结果表明：烷醇的促透能力与它们的脂溶性及羟基的位置有很好的相关性。烷醇的促透能力随着脂溶性的增大而增强，但是随着官能团羟基从链的末端移向中间而减弱。
　　개진경피급약계통적최상용방법시사용투피촉진제，촉투제능가역지감소약물투과피부적장애。수연화학촉진제적촉투작용이경득도료엄범연구，단타문적정량구효관계연구보도환불다견。본문용축보다원선성회귀분석，건립료16충완순촉투제적촉투능력여기이화삼수지간적상관방정식。결과표명：완순적촉투능력여타문적지용성급간기적위치유흔호적상관성。완순적촉투능력수착지용성적증대이증강，단시수착관능단간기종련적말단이향중간이감약。
The most common method to improve the transdermal delivery system is the use of penetration enhancers, and penetration enhancers can reversibly reduce barriers of medicines through the skin. Although the role of transdermal penetration of the chemical accelerator has been extensively studied, but their quantitative structure-activity relationship studies have reported rare. Stepwise multiple linear regression analysis, establish equation 16 alkanol penetration enhancer transdermal penetration capability between its physical and chemical parameters.