中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2013年
12期
1-5
,共5页
陈英杰%周大桥%童光东%贺劲松%邢宇锋
陳英傑%週大橋%童光東%賀勁鬆%邢宇鋒
진영걸%주대교%동광동%하경송%형우봉
乙型肝炎病毒携带者%免疫因子%中医药疗法%补肾健脾方%随机对照试验
乙型肝炎病毒攜帶者%免疫因子%中醫藥療法%補腎健脾方%隨機對照試驗
을형간염병독휴대자%면역인자%중의약요법%보신건비방%수궤대조시험
Hepatitis B virus carriers%Immunologic factors%TCM therapy%Bushen Jianpi recipe%Randomized controlled trial
目的：评价补肾健脾方对HBeAg阳性乙肝病毒携带者血清细胞因子的调节作用。方法：采用多中心、随机、双盲、对照的研究方法。400例HBeAg阳性乙肝病毒携带者随机分为治疗组和对照组，分别给予补肾健脾方、安慰剂治疗52周。观察治疗前后血清细胞因子IL-2、IL-4、IL-10、IFN-γ、TNF-α水平及HBV DNA载量的变化。结果：治疗52周后，补肾健脾方组患者的血清细胞因子IL-2和IFN-γ显著上升，TNF-α、IL-4和IL-10则明显下降（P<0.01）；治疗前后的各细胞因子差值比较，均优于安慰剂对照组（P<0.01）；而血清HBV DNA载量较基线下降>1 log10,>2 log10,>3 log10比例均显著高于安慰剂对照组（P<0.01）。结论：补肾健脾方通过调节Th1/Th2型细胞因子水平，打破HBV感染的免疫耐受状态，实现对HBV复制的抑制作用。
目的：評價補腎健脾方對HBeAg暘性乙肝病毒攜帶者血清細胞因子的調節作用。方法：採用多中心、隨機、雙盲、對照的研究方法。400例HBeAg暘性乙肝病毒攜帶者隨機分為治療組和對照組，分彆給予補腎健脾方、安慰劑治療52週。觀察治療前後血清細胞因子IL-2、IL-4、IL-10、IFN-γ、TNF-α水平及HBV DNA載量的變化。結果：治療52週後，補腎健脾方組患者的血清細胞因子IL-2和IFN-γ顯著上升，TNF-α、IL-4和IL-10則明顯下降（P<0.01）；治療前後的各細胞因子差值比較，均優于安慰劑對照組（P<0.01）；而血清HBV DNA載量較基線下降>1 log10,>2 log10,>3 log10比例均顯著高于安慰劑對照組（P<0.01）。結論：補腎健脾方通過調節Th1/Th2型細胞因子水平，打破HBV感染的免疫耐受狀態，實現對HBV複製的抑製作用。
목적：평개보신건비방대HBeAg양성을간병독휴대자혈청세포인자적조절작용。방법：채용다중심、수궤、쌍맹、대조적연구방법。400례HBeAg양성을간병독휴대자수궤분위치료조화대조조，분별급여보신건비방、안위제치료52주。관찰치료전후혈청세포인자IL-2、IL-4、IL-10、IFN-γ、TNF-α수평급HBV DNA재량적변화。결과：치료52주후，보신건비방조환자적혈청세포인자IL-2화IFN-γ현저상승，TNF-α、IL-4화IL-10칙명현하강（P<0.01）；치료전후적각세포인자차치비교，균우우안위제대조조（P<0.01）；이혈청HBV DNA재량교기선하강>1 log10,>2 log10,>3 log10비례균현저고우안위제대조조（P<0.01）。결론：보신건비방통과조절Th1/Th2형세포인자수평，타파HBV감염적면역내수상태，실현대HBV복제적억제작용。
Objective:To estimate the modulatory effect of Bushen Jianpi recipe on serum cytokines in HBeAg-positive hepatitis B virus carriers. Methods:With the multi-center, randomized, double-blinded and controlled methods, 400 cases of were randomly assigned to treated group and control group. During the 52-week treatments, Bushen Jianpi recipe was applied in treated group and placebo was adopted in control group. The serum cytokine levels, including IL-2、IL-4、IL-10、IFN-γand TNF-α, and HBV DNA level were detected pre-treatment and post-treatment in all patients. Results:After the 52-week treatments, in the Bushen Jianpi recipe treated group, the serum levels of IL-2 and IFN-γwere markedly increased, while the serum levels of TNF-α, IL-4 and IL-10 were obviously decreased(P<0.01). The variation of each cytokine level pre-treatment and post-treatment in the Bushen Jianpi recipe treated group was significantly different from that in the placebo control group (P<0.01). The proportions of patients in the Bushen Jianpi recipe treated group in whom serum HBV DNA levels decreased from the baseline by more than 1 log10, 2 log10, 3 log10 were significantly higher than those in the placebo control group(P<0.01). Conclusion:Bushen Jianpi recipe breaks the immunological tolerance of hepatitis B virus infection by modulating the level of Th1/Th2 type cytokines, to achieve the inhibition for HBV replication.
