CAJ | 학술논문

　　目的探讨国产阿德福韦酯片治疗活动性失代偿乙型肝炎肝硬化的疗效和安全性研究。方法两组均给以保肝降酶、对症以及血制品支持等治疗，观察组患者在对照组所有用治疗的基础上，加用阿德福韦酯片。结果两组患者在治疗后的结果显示，观察组的ALT复常率、HBV DNA转阴率、HBeAg转阴率明显高于对照组。Child-Pugh评分的变化观察组中有10例病情加重，对照组中有32例病情加重。血常规、尿常规及肾功能均未发生明显变化，均未表现出明显的不良反应。结论国产阿德福韦酯片治疗活动性失代偿乙型肝炎肝硬化的疗效好，安全性可靠，值得进行大力的推广与应用。
　　목적탐토국산아덕복위지편치료활동성실대상을형간염간경화적료효화안전성연구。방법량조균급이보간강매、대증이급혈제품지지등치료，관찰조환자재대조조소유용치료적기출상，가용아덕복위지편。결과량조환자재치료후적결과현시，관찰조적ALT복상솔、HBV DNA전음솔、HBeAg전음솔명현고우대조조。Child-Pugh평분적변화관찰조중유10례병정가중，대조조중유32례병정가중。혈상규、뇨상규급신공능균미발생명현변화，균미표현출명현적불량반응。결론국산아덕복위지편치료활동성실대상을형간염간경화적료효호，안전성가고，치득진행대력적추엄여응용。
Objective Investigate the efficacy and safety of domestic adefovir dipivoxil tablets to treat the active decompensated hepafic cirrhosis. Methods 100 patients divided into treatment group and control group. The control group is treated as usual, and the control group is treated on the addition of adefovir dipivoxil tablets. Results After the treatment, ALT normalization rate, HBV DNA negative rate and HBeAg negative rate are all higher in the treatment group than in the control group. Child-Pugh changes is better in the treatment than in the control group. Both groups are no signiifcant adverse reactions. Conclusion He efifcacy and safety of domestic adefovir dipivoxil tablets to treat the active decompensated liver hepaifc cirrhosis is very good, and worthy to be popularized.