中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
28期
40-42
,共3页
许丽琴%齐旭升%王素梅%潘同国
許麗琴%齊旭升%王素梅%潘同國
허려금%제욱승%왕소매%반동국
肿瘤坏死因子α%神经元特异性烯醇化酶%缺氧缺血性脑病%新生儿
腫瘤壞死因子α%神經元特異性烯醇化酶%缺氧缺血性腦病%新生兒
종류배사인자α%신경원특이성희순화매%결양결혈성뇌병%신생인
Tumor necrosis factor-alpha%Neuron-specific enolase%Hypoxic-ischemic encephalopathy%Newborn infant
目的 探讨血清肿瘤坏死因子(TNF)-α、神经元特异性烯醇化酶(NSE)与新生儿缺氧缺血性脑病(HIE)病情严重程度的关系.方法 选择46例HIE患儿作为HIE组,选择足月新生儿30例作为对照组,检测HIE组急性期和恢复期及不同临床分度、对照组的血清TNF-α与NSE水平,分析血清TNF-α与NSE水平和新生儿HIE病情严重程度的关系.结果 HIE组急性期血清TNF-α和NSE水平分别为(156.3±28.8) ng/L、(21.5 ±3.6) μg/L,HIE组恢复期分别为(80.7±26.1) ng/L、(10.6±1.7)μg/L,对照组分别为(76.3±24.4) ng/L、(9.4±1.6) μg/L.HIE组急性期血清TNF-α与NSE水平均显著高于HIE组恢复期和对照组,差异均有统计学意义(P＜0.05),HIE组恢复期和对照组比较差异无统计学意义(P＞0.05).轻度HIE患儿血清TNF-α与NSE水平分别为(88.5±25.6) ng/L、(9.7±2.4) μg/L,中度HIE患儿分别为(150.1±16.5) ng/L、(17.8±3.6) μg/L,重度HIE患儿分别为(197.3±30.2) ng/L、(23.6±4.3)μg/L.随着临床分度的加重,血清TNF-α、NSE水平呈逐渐增加的趋势,各临床分度间比较差异有统计学意义(P＜0.05)；轻度HIE患儿血清TNF-α与NSE水平与对照组比较差异无统计学意义(P＞0.05),中、重度HIE患儿则明显高于对照组,差异有统计学意义(P＜0.05).Spearman等级相关分析显示,血清TNF-α和NSE水平与HIE临床分度均呈正相关(r=0.54、0.57,P＜0.01或＜0.05)；Pearson相关分析显示,TNF-α与NSE也呈正相关(r=0.46,P＜ 0.05).结论 HIE患儿TNF-α和NSE升高且与新生儿HIE的严重程度呈正相关,能较敏感地反映HIE患儿病情严重程度,可以作为新生儿HIE病情严重程度的临床评估指标.
目的 探討血清腫瘤壞死因子(TNF)-α、神經元特異性烯醇化酶(NSE)與新生兒缺氧缺血性腦病(HIE)病情嚴重程度的關繫.方法 選擇46例HIE患兒作為HIE組,選擇足月新生兒30例作為對照組,檢測HIE組急性期和恢複期及不同臨床分度、對照組的血清TNF-α與NSE水平,分析血清TNF-α與NSE水平和新生兒HIE病情嚴重程度的關繫.結果 HIE組急性期血清TNF-α和NSE水平分彆為(156.3±28.8) ng/L、(21.5 ±3.6) μg/L,HIE組恢複期分彆為(80.7±26.1) ng/L、(10.6±1.7)μg/L,對照組分彆為(76.3±24.4) ng/L、(9.4±1.6) μg/L.HIE組急性期血清TNF-α與NSE水平均顯著高于HIE組恢複期和對照組,差異均有統計學意義(P＜0.05),HIE組恢複期和對照組比較差異無統計學意義(P＞0.05).輕度HIE患兒血清TNF-α與NSE水平分彆為(88.5±25.6) ng/L、(9.7±2.4) μg/L,中度HIE患兒分彆為(150.1±16.5) ng/L、(17.8±3.6) μg/L,重度HIE患兒分彆為(197.3±30.2) ng/L、(23.6±4.3)μg/L.隨著臨床分度的加重,血清TNF-α、NSE水平呈逐漸增加的趨勢,各臨床分度間比較差異有統計學意義(P＜0.05)；輕度HIE患兒血清TNF-α與NSE水平與對照組比較差異無統計學意義(P＞0.05),中、重度HIE患兒則明顯高于對照組,差異有統計學意義(P＜0.05).Spearman等級相關分析顯示,血清TNF-α和NSE水平與HIE臨床分度均呈正相關(r=0.54、0.57,P＜0.01或＜0.05)；Pearson相關分析顯示,TNF-α與NSE也呈正相關(r=0.46,P＜ 0.05).結論 HIE患兒TNF-α和NSE升高且與新生兒HIE的嚴重程度呈正相關,能較敏感地反映HIE患兒病情嚴重程度,可以作為新生兒HIE病情嚴重程度的臨床評估指標.
목적 탐토혈청종류배사인자(TNF)-α、신경원특이성희순화매(NSE)여신생인결양결혈성뇌병(HIE)병정엄중정도적관계.방법 선택46례HIE환인작위HIE조,선택족월신생인30례작위대조조,검측HIE조급성기화회복기급불동림상분도、대조조적혈청TNF-α여NSE수평,분석혈청TNF-α여NSE수평화신생인HIE병정엄중정도적관계.결과 HIE조급성기혈청TNF-α화NSE수평분별위(156.3±28.8) ng/L、(21.5 ±3.6) μg/L,HIE조회복기분별위(80.7±26.1) ng/L、(10.6±1.7)μg/L,대조조분별위(76.3±24.4) ng/L、(9.4±1.6) μg/L.HIE조급성기혈청TNF-α여NSE수평균현저고우HIE조회복기화대조조,차이균유통계학의의(P＜0.05),HIE조회복기화대조조비교차이무통계학의의(P＞0.05).경도HIE환인혈청TNF-α여NSE수평분별위(88.5±25.6) ng/L、(9.7±2.4) μg/L,중도HIE환인분별위(150.1±16.5) ng/L、(17.8±3.6) μg/L,중도HIE환인분별위(197.3±30.2) ng/L、(23.6±4.3)μg/L.수착림상분도적가중,혈청TNF-α、NSE수평정축점증가적추세,각림상분도간비교차이유통계학의의(P＜0.05)；경도HIE환인혈청TNF-α여NSE수평여대조조비교차이무통계학의의(P＞0.05),중、중도HIE환인칙명현고우대조조,차이유통계학의의(P＜0.05).Spearman등급상관분석현시,혈청TNF-α화NSE수평여HIE림상분도균정정상관(r=0.54、0.57,P＜0.01혹＜0.05)；Pearson상관분석현시,TNF-α여NSE야정정상관(r=0.46,P＜ 0.05).결론 HIE환인TNF-α화NSE승고차여신생인HIE적엄중정도정정상관,능교민감지반영HIE환인병정엄중정도,가이작위신생인HIE병정엄중정도적림상평고지표.
Objective To investigate the correlation between serum tumor necrosis factor (TNF)-α,neuron-specific enolase (NSE)and the degree of hypoxic-ischemic encephalopathy (HIE).Methods Forty-six HIE patients in acute and convalescent stage and 30 full-term newborn infant were enrolled in this study.The level of serum of TNF-α and NSE were detected.The relationship between TNF-α,NSE level and severity of HIE was analyzed.Results The level of serum TNF-α and NSE in acute stage of HIE group were (156.3 ± 28.8) ng/L and (21.5 ± 3.6) μg/L,in convalescent stage of HIE group were (80.7 ± 26.1) ng/L and (10.6 ± 1.7) μ g/L,and in control group were (76.3 ± 24.4) ng/L and (9.4 ± 1.6) μ g/L.The level of serum TNF-α and NSE in acute stage of HIE group were significantly higher than those in convalescent stage of HIE group and control group (P ＜ 0.05).The level of serum TNF-α and NSE in convalescent stage of HIE group had no significant difference compared with those in control group (P ＞ 0.05).The level of serum TNF-α and NSE in mild HIE group were (88.5 ± 25.6) ng/L and (9.7 ± 2.4) μ g/L,in moderate HIE group were (150.1 ± 16.5) ng/L and (17.8 ± 3.6) μ g/L,and in severe HIE group were (197.3 ± 30.2) ng/L and (23.6 ±4.3) μg/L.The level of TNF-αand NSE were increased with the aggravation of HIE and there had significant difference among different degree of HIE(P ＜ 0.05).The level of serum TNF-α and NSE in mild HIE group and control group had no significant difference (P ＞ 0.05),and there had significant difference between moderate HIE group,severe HIE group and control group (P ＜ 0.05).Spearman rank correlation analysis showed that the level of TNF-α and NSE had positive correlation with the degree of HIE (r =0.54,0.57,P ＜ 0.01 or ＜ 0.05).Pearson correlation analysis showed that the level of TNF-α had positive correlation with the level of NSE (r =0.46,P ＜ 0.05).Conclusions The variation of TNF-α and NSE level in HIE newborn infant is parallel to the severity of the disease,which can sensitively reflect the severity of HIE.Therefore,TNF-α and NSE may be used as vital indexes for the evaluation of the severity of HIE.
