CAJ | 학술논문

　　目的探讨表皮生长因子受体(EGFR)和Ki67在上皮性卵巢癌中的表达及临床意义。方法采用免疫组化SP法检测EGFR和Ki67在上皮性卵巢癌、卵巢良性肿瘤和正常卵巢组织的表达情况。结果 EGFR和Ki67在上皮性卵巢癌组织与正常卵巢和卵巢良性肿瘤组织阳性的表达率有统计学差异(P<0.05)。EGFR和Ki67表达在肿瘤的组织学分级、临床分期和有无淋巴结转移中具有统计学差异(P<0.05)。结论 EGFR和Ki67在上皮性卵巢癌的发生、发展过程中起着重要的作用。
　　목적탐토표피생장인자수체(EGFR)화Ki67재상피성란소암중적표체급림상의의。방법채용면역조화SP법검측EGFR화Ki67재상피성란소암、란소량성종류화정상란소조직적표체정황。결과 EGFR화Ki67재상피성란소암조직여정상란소화란소량성종류조직양성적표체솔유통계학차이(P<0.05)。EGFR화Ki67표체재종류적조직학분급、림상분기화유무림파결전이중구유통계학차이(P<0.05)。결론 EGFR화Ki67재상피성란소암적발생、발전과정중기착중요적작용。
Objective To study the expression and clinical significance of EGFR and Ki67 in epithelial ovarian cancer. Methods The expression of EGFR and Ki67 in tissues of epithelial ovarian cancer, benign tumor and normal ovary were detected by SP immunohistochemistry. Results The positive expression rates of EGFR and Ki67 in epithelial ovarian cancer tissue were significantly different from those in normal ovary and ovarian benign tumors(P<0.05). The expression of EGFR and Ki67 in histological grade and clinical stage was significantly different(P<0.05). Conclusion EGFR and Ki67 play an important role in the development of epithelial ovarian cancer.