CAJ | 학술논문

　　目的分析医用透明质酸钠在预防甲状腺术后切口粘连方面的作用，并观察患者并发症的发生情况。方法在我院进行各类颈部甲状腺手术的患者中选择68例进行研究，其中切口应用医用透明质酸钠的患者34例组成干预组，切口不做任何处理的患者34例组成对照组，对照组和干预组的患者的年龄、性别、病情及手术情况等基本临床资料之间的差异无统计学意义（P>0.05）。对照组患者颈前肌群深面、颈阔肌深面及皮肤切口缝合后不做任何处理，干预组患者颈前肌群深面、颈阔肌深面及皮肤切口缝合后涂抹透明质酸钠，比较两组患者手术半年后患者的切口粘连情况，及切口感染等并发症的发生率。结果对照组患者半年后切口粘连的发生率为5.88%，干预组患者切口粘连的发生率为29.41%，两组之间的差异明显且有统计学意义。对照组出现皮下积液的患者4人，切口感染者1人，患者均未出现过敏性反应或者排异反应；干预组出现皮下积液的患者3人，切口感染1人，患者均未出现过敏和排异反应，二者之间的差异不大，无统计学意义。结论医用透明质酸钠可以有效的预防甲状腺术后切口的粘连，同时不会增加患者的并发症的发生率。既保证了伤口愈合的有效性，同时又保证了患者的安全，在我们临床实践中可以广泛应用。
　　목적분석의용투명질산납재예방갑상선술후절구점련방면적작용，병관찰환자병발증적발생정황。방법재아원진행각류경부갑상선수술적환자중선택68례진행연구，기중절구응용의용투명질산납적환자34례조성간예조，절구불주임하처리적환자34례조성대조조，대조조화간예조적환자적년령、성별、병정급수술정황등기본림상자료지간적차이무통계학의의（P>0.05）。대조조환자경전기군심면、경활기심면급피부절구봉합후불주임하처리，간예조환자경전기군심면、경활기심면급피부절구봉합후도말투명질산납，비교량조환자수술반년후환자적절구점련정황，급절구감염등병발증적발생솔。결과대조조환자반년후절구점련적발생솔위5.88%，간예조환자절구점련적발생솔위29.41%，량조지간적차이명현차유통계학의의。대조조출현피하적액적환자4인，절구감염자1인，환자균미출현과민성반응혹자배이반응；간예조출현피하적액적환자3인，절구감염1인，환자균미출현과민화배이반응，이자지간적차이불대，무통계학의의。결론의용투명질산납가이유효적예방갑상선술후절구적점련，동시불회증가환자적병발증적발생솔。기보증료상구유합적유효성，동시우보증료환자적안전，재아문림상실천중가이엄범응용。
Objective To analyze the effect of sodium hyaluronate in the prevention of thyroid postoperative incision adhesion, and observation of complications. Methods The study was performed in 68 patients with various choices of thyroid operation in our hospital, the patients with incision application of sodium hyaluronate in 34 cases of the components of the intervention group;the control group are 34 patients whose incisions without any treatment, the difference between patients and control group and intervention group by age, gender, disease and operation and other basic clinical data had no statistical signiifcance (P>0.05). Patients in the control group of anterior cervical muscle group, the deep surface of platysma deep surface and skin incision suture without any treatment, patients in the intervention group of anterior cervical muscle group, the deep surface of platysma deep surface and skin incision suture after smearing of sodium hyaluronate, compared two groups of patients six months after operation in patients with adhesions, the incidence and infection of incisional wound complications. Results The patients in the control group after six months of incision adhesion occurred in 5.88%of patients in the intervention group, incision adhesion rate was 29.41%, the difference between the two groups was signiifcantly and there was statistical signiifcance. The control group were subcutaneous effusion in 4, wound infection in 1 patients, there were no allergic reaction or rejection;the intervention group patients with subcutaneous effusion in 3, wound infection in 1 patients, all did not appear allergy and rejection, the difference between them is small, no statistical signiifcance. Conclusion Sodium hyaluronate can prevent postoperative adhesion was effective, and does not increase the incidence of complications in patients. Both to ensure the effectiveness of wound healing, but also ensure the safety of patients, and can be widely applied in our clinical practice.