CAJ | 학술논문

　　目的探讨急性髓系白血病（AML）患者外周血T淋巴细胞亚群、DNT细胞、NK细胞的表达水平及其临床意义。方法采用流式细胞术对40例初发AML患者、32例AML完全缓解（CR）患者及20例正常人外周血T淋巴细胞亚群、DNT细胞及NK细胞水平进行检测。结果初发AML组与正常对照组比较，CD4+细胞、CD4+/CD8+比值、DNT细胞及NK细胞明显降低（P＜0.05）；CD3+细胞、CD8+细胞变化不显著（P>0.05）。复治CR组与对照组比较，NK细胞明显降低（P＜0.05），其他各值差异无统计学意义。结论初发AML患者的T淋巴细胞亚群、DNT细胞、NK细胞变化明显，而治疗缓解后淋巴亚群基本恢复正常，说明T淋巴细胞亚群、DNT细胞、NK细胞水平检测在评价AML疗效及判断预后方面具有一定的临床价值。
　　목적탐토급성수계백혈병（AML）환자외주혈T림파세포아군、DNT세포、NK세포적표체수평급기림상의의。방법채용류식세포술대40례초발AML환자、32례AML완전완해（CR）환자급20례정상인외주혈T림파세포아군、DNT세포급NK세포수평진행검측。결과초발AML조여정상대조조비교，CD4+세포、CD4+/CD8+비치、DNT세포급NK세포명현강저（P＜0.05）；CD3+세포、CD8+세포변화불현저（P>0.05）。복치CR조여대조조비교，NK세포명현강저（P＜0.05），기타각치차이무통계학의의。결론초발AML환자적T림파세포아군、DNT세포、NK세포변화명현，이치료완해후림파아군기본회복정상，설명T림파세포아군、DNT세포、NK세포수평검측재평개AML료효급판단예후방면구유일정적림상개치。
Objective To explore the expression and signiifcance of the T cell subsets, DNT cells, NK cells in peripheral blood of patients with acute myeloid leukemia (AML). Methods The different level of peripheral blood T lymphocyte subsets, DNT cells, NK cells of 40 acute myeloid leukemia patients, 32 completely remitted (CR) patients and 20 normal controls were detected with lfow cytometry. Results Compared with the normal controls , the percentage of CD4+cells, DNT cells, NK cells and the ratio of CD4+/CD8+decreased obviously in newly diagnosed AML group (P<0.05), while the change of percentage of CD3+cells and CD8+cells was not signiifcant(P>0.05). Compared with the normal controls the percentage of NK cells decreased obviously in CR group (P<0.05).There was no signiifcant difference in other data between CR group and the control group (P>0105). Conclusion Lymphocyte subsets, DNT cells, NK cells were markedly changed in AML, but recovered essentially to normal after treatment. It shows that detection of T lymphocyte subsets, DNT cells, NK cells are clinically value on evaluation of therapeutic effect and prognosis of acute myeloid leukemia.