CAJ | 학술논문

　　目的探讨血清胱抑素C（CysC）在糖尿病肾病（DN）诊断中的意义。方法将95例2型糖尿病患者根据24 h尿微量蛋白排泄率（UAER）水平分为正常蛋白尿组、微量蛋白尿组、临床蛋白尿组，选取同期的35名健康人员为正常对照组，检测4组人员的血清CysC浓度并进行比较。结果与正常对照组（0.55±0.16）mg/L相比，正常蛋白尿组、微量蛋白尿组、临床蛋白尿组的CysC浓度均明显升高[分别为（0.73±0.18）mg/L、（1.21±0.25）mg/L、（1.87±0.24）mg/L]（均P＜0.01），且3组间的CysC水平差异有统计学意义（P＜0.01），同时，微量蛋白尿组与临床蛋白尿组血清CysC浓度与尿微量蛋白排泄率（UAER）呈显著正相关（r分别为0.083，0.675，P＜0.01）。结论血清CysC是反映糖尿病肾病患者肾功能的理想指标，对诊断糖尿病肾病早期肾损伤有重要的意义。
　　목적탐토혈청광억소C（CysC）재당뇨병신병（DN）진단중적의의。방법장95례2형당뇨병환자근거24 h뇨미량단백배설솔（UAER）수평분위정상단백뇨조、미량단백뇨조、림상단백뇨조，선취동기적35명건강인원위정상대조조，검측4조인원적혈청CysC농도병진행비교。결과여정상대조조（0.55±0.16）mg/L상비，정상단백뇨조、미량단백뇨조、림상단백뇨조적CysC농도균명현승고[분별위（0.73±0.18）mg/L、（1.21±0.25）mg/L、（1.87±0.24）mg/L]（균P＜0.01），차3조간적CysC수평차이유통계학의의（P＜0.01），동시，미량단백뇨조여림상단백뇨조혈청CysC농도여뇨미량단백배설솔（UAER）정현저정상관（r분별위0.083，0.675，P＜0.01）。결론혈청CysC시반영당뇨병신병환자신공능적이상지표，대진단당뇨병신병조기신손상유중요적의의。
Objective To discuss the signiifcance of serum cystatin C ( CysC ) in the diagnosis of diabetic nephropathy ( DN ). Methods Ninety-ifve cases of type 2 diabetic patients according to 24 h urinary protein excretion rate ( UAER ) levels were divided into normal albuminuria group, microalbuminuria group and clinical proteinuria group , 35 health personnel were chosen as normal control group, the level of serum CysC concentration of four groups were and compared.Results Compared with the normal control group [( 0.55 ± 0.16)mg/L ] in normal albuminuria group, microalbuminuria group and clinical proteinuria group, the concentrations of CysC were signiifcantly increased ( 0.73 ± 0.18)mg/L, ( 1.21 ± 0.25)mg/L, (1.87 ± 0.24)mg/L (P<0.01 ), and the 3 groups of between CysC level has signiifcant difference (P<0.01), at the same time, microalbuminuria or clinical proteinuria group serum CysC concentrations and urinary protein excretion rate (UAER) showed signiifcant positive correlation ( r=0.083, 0.675,P<0.01 ).Conclusion Serum CysC is a relfection of renal function in patients with diabetic nephropathy ideal index, it has important signiifcance in the diagnosis of early diabetic nephropathy renal injury.