当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2013年
22期
36-36,37
,共2页
高尿酸血症%糖耐量减低(IGT)%糖代谢
高尿痠血癥%糖耐量減低(IGT)%糖代謝
고뇨산혈증%당내량감저(IGT)%당대사
Hyperuricemia(HUA)%Impaired glucose tolerance(IGT)%Glucose metablism
目的探讨控制高尿酸血症对糖耐量减低（IGT）患者糖代谢的影响。方法将40例住院IGT合并高尿酸血症的病人随机分成2组，对照组单纯饮食控制治疗，研究组在单纯饮食控制治疗基础上加用别嘌呤醇降尿酸治疗。以100 g馒头餐试验评估β细胞功能，观察治疗前后变化。结果经积极降尿酸治疗后，研究组HOMA-IR低于对照组，hsCRP低于对照组，两组间差别有统计学意义。结论 IGT合并高尿酸血症的病人积极控制高尿酸血症有利于降低胰岛素抵抗，纠正糖代谢紊乱，其机制可能与减少炎症因子有关。
目的探討控製高尿痠血癥對糖耐量減低（IGT）患者糖代謝的影響。方法將40例住院IGT閤併高尿痠血癥的病人隨機分成2組，對照組單純飲食控製治療，研究組在單純飲食控製治療基礎上加用彆嘌呤醇降尿痠治療。以100 g饅頭餐試驗評估β細胞功能，觀察治療前後變化。結果經積極降尿痠治療後，研究組HOMA-IR低于對照組，hsCRP低于對照組，兩組間差彆有統計學意義。結論 IGT閤併高尿痠血癥的病人積極控製高尿痠血癥有利于降低胰島素牴抗，糾正糖代謝紊亂，其機製可能與減少炎癥因子有關。
목적탐토공제고뇨산혈증대당내량감저（IGT）환자당대사적영향。방법장40례주원IGT합병고뇨산혈증적병인수궤분성2조，대조조단순음식공제치료，연구조재단순음식공제치료기출상가용별표령순강뇨산치료。이100 g만두찬시험평고β세포공능，관찰치료전후변화。결과경적겁강뇨산치료후，연구조HOMA-IR저우대조조，hsCRP저우대조조，량조간차별유통계학의의。결론 IGT합병고뇨산혈증적병인적겁공제고뇨산혈증유리우강저이도소저항，규정당대사문란，기궤제가능여감소염증인자유관。
Objective To explore the effect of controlling of hyperuricemia on HOMA-IR and glucose metabolism. Methods 40 patients of hyperuricemia (HUA)with impaired glucose tolerence(IGT)were divided into study group and controlled group. The levels of glucose, insulin, uricemia, hs-CRP were determined, HOMA-IR were calculated. The controlled group was treated by only mile-controlled;for study group, treatment to reduce uricemia with mile-controlled added allopurinol for 6 months. The 100 g carbohydrate(steamd bread)challeng of insulin releasing test was performed to evaluate B cell function. Results The study group after treatment showed lower levels of FPG、HOMA-IR and hs-CRP(all P<0.05). Conclusion Control of hyperuricemia could reduce insulin resistance, improve B cell function and glucose metabolism.
