CAJ | 학술논문

　　目的探讨老年痴呆病的发病机制及临床采用中西医结合药物治疗效果。方法就诊的50例老年痴呆病患者随机分为观察组和对照组，各25例。对照组临床给予西药吡拉西坦片，每天3次，每次2片（0.8 g）进行治疗，观察组在对照组的基础上给予自拟中药补肾益智汤治疗，观察两组患者治疗前后的效果。结果对照组显效11例，有效7例，好转5例，无效7例，总有效率为76.67%；观察组30例患者种有效显效18例，有效6例，好转4例，无效2例，总有效率为93.33%。观察组与对照组比较差异有统计学意义（P＜0.05）。结论老年痴呆病发病机制主要与基因突变、胆碱能缺失等有关，临床采用中西医结合治疗总有效率高，效果显著，值得临床推广使用。
　　목적탐토노년치태병적발병궤제급림상채용중서의결합약물치료효과。방법취진적50례노년치태병환자수궤분위관찰조화대조조，각25례。대조조림상급여서약필랍서탄편，매천3차，매차2편（0.8 g）진행치료，관찰조재대조조적기출상급여자의중약보신익지탕치료，관찰량조환자치료전후적효과。결과대조조현효11례，유효7례，호전5례，무효7례，총유효솔위76.67%；관찰조30례환자충유효현효18례，유효6례，호전4례，무효2례，총유효솔위93.33%。관찰조여대조조비교차이유통계학의의（P＜0.05）。결론노년치태병발병궤제주요여기인돌변、담감능결실등유관，림상채용중서의결합치료총유효솔고，효과현저，치득림상추엄사용。
Objective To investigate the pathogenesis of alzheimer's disease and clinical effects of drug treatment.Methods In that hospital, 50 cases of alzheimer's disease patients were divided into the observation group and the control group with 25 cases in each group.The control group treated with piracetam in clinical treatment, three times a day, two tablets each time (0.8g) the observation group was given Chinese medicine Bushen Yizhi decoction based on control group and the effect were observed before and after treatment in two groups. Results In the control group 11 cases were excellent, effective in 7 cases, 5 cases were improved, 7 cases were invalid, the total efifciency rate was 76.67%, the observation group 30 cases were excellent,effective in 18 cases, effective in 6 cases, 4 cases were improved, 2 cases were ineffective, the total effective rate was 93.33%,there was signiifcant difference between treatment group and control group ( P<0.05). Conclusion Alzheimer's disease pathogenesis and gene mutation, cholinergic deletion, Clinical use of Integrated Chinese and Western medicine treatment the total effective rate is high, signiifcant effect, worthy of clinical use.