CAJ | 학술논문

椎间盘退变是多种因素长期慢性刺激椎间盘，从而引起的椎间盘结构稳定性下降，逐步缓慢发生相关变化的反应过程。通过对动物退变椎间盘模型的研究，可以为人椎间盘退变疾病的研究提供重要手段。随着动物模型制作手段不断丰富及控制指标精确程度不断提高，动物所模拟人椎间盘退变模型相似度有了显著提高，因此动物造模在椎间盘退变性疾病的研究中将具有更为广阔的发展前景。本文就近年来各种常用椎间盘退变模型的研究进展作一综述。
추간반퇴변시다충인소장기만성자격추간반，종이인기적추간반결구은정성하강，축보완만발생상관변화적반응과정。통과대동물퇴변추간반모형적연구，가이위인추간반퇴변질병적연구제공중요수단。수착동물모형제작수단불단봉부급공제지표정학정도불단제고，동물소모의인추간반퇴변모형상사도유료현저제고，인차동물조모재추간반퇴변성질병적연구중장구유경위엄활적발전전경。본문취근년래각충상용추간반퇴변모형적연구진전작일종술。
Intervertebral disc degeneration is a variety of factors, long-term and chronic stimulation of intervertebral disc, intervertebral disc structure stability decreased due to the reaction process, gradually change. Through the study of the animal model of degenerative intervertebral disc, study for the human intervertebral disc degeneration diseases provide an important means of. As the animal model making means continuously enriched and control index of accurate degree raise constantly, the simulated animal intervertebral disc degeneration model similarity has been signiifcantly improved, thus making animal model has a broad prospect in the research the degenerative disc disease. This article reviews the progress in recent years a variety of commonly used animal model of intervertebral disc degeneration.