国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
6期
804-806
,共3页
马洺远%林纲毅%黄丽妹%郑桂贞
馬洺遠%林綱毅%黃麗妹%鄭桂貞
마명원%림강의%황려매%정계정
膀胱癌%髂内动脉化疗栓塞(灌注)术%预防性%抗生素
膀胱癌%髂內動脈化療栓塞(灌註)術%預防性%抗生素
방광암%가내동맥화료전새(관주)술%예방성%항생소
Bladder carcinoma%Internal iliac artery chemoembolization or arterial infusion chemotherapy%Prophylactic use%Antibiotic
目的 探讨膀胱癌髂内动脉化疗栓塞(灌注)术后预防性应用抗生素的作用.方法 入组对象为未行外科手术或已行膀胱癌部分切除术的膀胱癌患者,共60例,行髂内动脉化疗栓塞或灌注术,共85例次.随机分为两组:介入术后应用环丙沙星组(预防组),介入术后不用抗生素组(非预防组).术后观察体温、外周血白细胞计数、中性粒细胞计数、尿常规及体征1个月.对疑似感染病例行血、尿培养.比较两组术后感染率.结果 预防组2例感染,感染率5％(2/42).非预防组3例感染,感染率为7％(3/43).两组术后感染率比较分析差异无统计学意义(P＞0.05).结论 膀胱癌髂内动脉化疗栓塞或灌注术患者一般不必预防性应用抗生素,但某些患者(特别是行化疗栓塞者)应综合考虑术式、患者的体质及免疫力等多方面因素,必要时须预防性应用抗生素治疗.
目的 探討膀胱癌髂內動脈化療栓塞(灌註)術後預防性應用抗生素的作用.方法 入組對象為未行外科手術或已行膀胱癌部分切除術的膀胱癌患者,共60例,行髂內動脈化療栓塞或灌註術,共85例次.隨機分為兩組:介入術後應用環丙沙星組(預防組),介入術後不用抗生素組(非預防組).術後觀察體溫、外週血白細胞計數、中性粒細胞計數、尿常規及體徵1箇月.對疑似感染病例行血、尿培養.比較兩組術後感染率.結果 預防組2例感染,感染率5％(2/42).非預防組3例感染,感染率為7％(3/43).兩組術後感染率比較分析差異無統計學意義(P＞0.05).結論 膀胱癌髂內動脈化療栓塞或灌註術患者一般不必預防性應用抗生素,但某些患者(特彆是行化療栓塞者)應綜閤攷慮術式、患者的體質及免疫力等多方麵因素,必要時鬚預防性應用抗生素治療.
목적 탐토방광암가내동맥화료전새(관주)술후예방성응용항생소적작용.방법 입조대상위미행외과수술혹이행방광암부분절제술적방광암환자,공60례,행가내동맥화료전새혹관주술,공85례차.수궤분위량조:개입술후응용배병사성조(예방조),개입술후불용항생소조(비예방조).술후관찰체온、외주혈백세포계수、중성립세포계수、뇨상규급체정1개월.대의사감염병례행혈、뇨배양.비교량조술후감염솔.결과 예방조2례감염,감염솔5％(2/42).비예방조3례감염,감염솔위7％(3/43).량조술후감염솔비교분석차이무통계학의의(P＞0.05).결론 방광암가내동맥화료전새혹관주술환자일반불필예방성응용항생소,단모사환자(특별시행화료전새자)응종합고필술식、환자적체질급면역력등다방면인소,필요시수예방성응용항생소치료.
Objective To discuss the necessity of prophylactic use of antibiotics after interventional procedures for bladder carcinoma.Methods A total of 60 patients with bladder carcinoma without surgery or having partial resection were enrolled in this study.A total of 85 times of internal iliac artery chemoembolization or arterial infusion chemotherapy were performed in 60 patients,who were randomly divided into two groups.After the procedure,patients in group A received ciprofloxacin,while patients in group B received no antibiotics.Patients were followed up for one month.Postoperative observations included body temperature,WBC count,neutrophil count,routine urine and patients' physical condition.Blood and urine culture were performed when patient was suspected of having infection.The infection rates were compared between two groups.Result Infection occurred in 2 cases of group A (5％) and in 3 cases of group B (7％),without statistically significant difference between two groups (P ＞ 0.05).Conclusions After interventional procedures for bladder carcinoma,prophylactic use of antibiotics is not necessary for patients who carry no high risk to infection before treatment.But some patients,especially in patients with chemotherapy embolism,should consider treatment method,patient's constitution,immunity and so on.They should receive preventive antibiotic treatment when necessary.
