CAJ | 학술논문

目的：探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)、微血管密度(microvascular density,MVD)表达与多层螺旋 CT (multi-slicespiral computed tomography,MSCT)肺灌注成像的关系。方法对80例肺内单发结节患者行MSCT肺灌注扫描,其中45例非小细胞肺癌(non-small cell lung carcinoma,NSCLC )获得与灌注成像兴趣区相当的病理层面,采用免疫组化的方法观察 VEGF 和 MVD 表达。用Spearman相关分析探讨45例 NSCLC患者灌注参数与 MVD和 VEGF表达的相互关系。结果 VEGF与MVD在肿瘤组织中呈异质性表达。灌注参数血流量(BF)与VEGF与MVD相关(P<0.05),强化峰值(PEI)和对比剂到达峰值时间(TTP)与MVD相关(P<0.05)。结论肺癌灌注成像部分参数与 MVD与 VEGF有一定的相关性。
목적：탐토혈관내피생장인자(vascular endothelial growth factor,VEGF)、미혈관밀도(microvascular density,MVD)표체여다층라선 CT (multi-slicespiral computed tomography,MSCT)폐관주성상적관계。방법대80례폐내단발결절환자행MSCT폐관주소묘,기중45례비소세포폐암(non-small cell lung carcinoma,NSCLC )획득여관주성상흥취구상당적병리층면,채용면역조화적방법관찰 VEGF 화 MVD 표체。용Spearman상관분석탐토45례 NSCLC환자관주삼수여 MVD화 VEGF표체적상호관계。결과 VEGF여MVD재종류조직중정이질성표체。관주삼수혈류량(BF)여VEGF여MVD상관(P<0.05),강화봉치(PEI)화대비제도체봉치시간(TTP)여MVD상관(P<0.05)。결론폐암관주성상부분삼수여 MVD여 VEGF유일정적상관성。
Objective To investigate the relationship of the expression of vascular endothelial growth factor (VEGF)and the mi-crovessel density (MVD)with multi-slice spiral CT perfusion imaging.Methods 80 patients with solitary pulmonary nodules under-went perfusion scan by 16-slice spiral CT.Among them,45 diagnosed as lung cancer by pathology were enrolled in the study.After surgery,the slice of the pecimen was selected similar to the corresponding slice of CT images,and the immunohistochemical staining was performed to determine the expression of VEGF and the MVD.Spearman correlation analysis was used to determine the rela-tionship of expression of VEGF and the MVD with CT perfusion parameters.Results There was more expression of VEGF and the MVD in NSCLC.There were positive correlations between VEGF,MVD and BF (both P<0.05).The peak enhancement image (PEI)and TTP have significant correlations with MVD (P<0.05).Conclusion Some parameters of lung CT perfusion imaging are correlated with MVD and VEGF.