CAJ | 학술논문

目的：研究超敏C-反应蛋白(Hs-CRP)和同型半胱氨酸(HCY)水平与急性缺血性脑卒中短期预后的关联性。方法前瞻性研究189例首次发病的急性缺血性脑卒中患者。入院后进行血清Hs-CRP、HCY水平检测与美国国立卫生研究院卒中量表(NI-HSS)评分。入院90 d后通过改良Rankin量表(mRS)测定短期功能结果。结果脑卒中组血清Hs-CRP和HCY水平显著高于健康对照组(P<0.001)。调整NIHSS和年龄等其他危险因素后，Hs-CRP和HCY是功能结果和死亡的独立的预测因素。通过受试者操作特征曲线(ROC)曲线下面积分析，HCY和HS-CRP结合模型的预测准确度明显高于各生物标志物单独测量和NIHSS评分。结论 Hs-CRP和HCY是脑卒中短期预后的独立预测因素。组合模型可以提供额外的预后信息。
목적：연구초민C-반응단백(Hs-CRP)화동형반광안산(HCY)수평여급성결혈성뇌졸중단기예후적관련성。방법전첨성연구189례수차발병적급성결혈성뇌졸중환자。입원후진행혈청Hs-CRP、HCY수평검측여미국국립위생연구원졸중량표(NI-HSS)평분。입원90 d후통과개량Rankin량표(mRS)측정단기공능결과。결과뇌졸중조혈청Hs-CRP화HCY수평현저고우건강대조조(P<0.001)。조정NIHSS화년령등기타위험인소후，Hs-CRP화HCY시공능결과화사망적독립적예측인소。통과수시자조작특정곡선(ROC)곡선하면적분석，HCY화HS-CRP결합모형적예측준학도명현고우각생물표지물단독측량화NIHSS평분。결론 Hs-CRP화HCY시뇌졸중단기예후적독립예측인소。조합모형가이제공액외적예후신식。
Objective To explore the relationship of high-sensitivity C-reactive protein (Hs-CRP), homocysteine (HCY) levels and the short-term outcome of acute ischemic stroke (AIS). Methods 189 patients with AIS were included. Serum Hs-CRP, HCY levels and Nation-al Institute of Health Stroke Scale (NIHSS) were assessed after admission. Short-term functional outcome was measured by modified Rankin Scale (mRS) 90 d after admission. Results The serum Hs-CRP and HCY levels were significantly higher in AIS patients than in nor-mal controls (P<0.001). Adjusting age and the NIHSS score, Hs-CRP and HCY were independent prognostic markers of functional outcome and death in patients with AIS. In receiver operating characteristic curve (ROC) analysis, the prognostic accuracy of combined model (HCY and Hs-CRP) was higher than that of biomarkers measured alone and the NIHSS score. Conclusion Hs-CRP and HCY are independent pre-dictors of short-term outcome and mortality after AIS. Combined model may provide additional general prognostic information.