药品评价
藥品評價
약품평개
DRUG REEVALUATION
2014年
18期
33-34,37
,共3页
血药浓度监测%丙戊酸钠%卡马西平%苯巴比妥%苯妥英钠
血藥濃度鑑測%丙戊痠鈉%卡馬西平%苯巴比妥%苯妥英鈉
혈약농도감측%병무산납%잡마서평%분파비타%분타영납
Blood Concentration Monitoring%Valproate%Carbamazepine%Phenobarbital%Phenytoin
目的：总结我院近3年4种抗癫痫药物的血药浓度监测结果，为临床安全、合理应用抗癫痫药物提供参考。方法：运用回顾性研究方法对我院2011年1月～2014年5月共1692例抗癫痫药物监测数据进行分析。结果：丙戊酸钠(valproate，VPA)、卡马西平(carbamazepine，CBZ)、苯巴比妥(phenobarbital，PB)和苯妥英钠(phenytoin，PHT)的监测频率(例/人)分别为2.46、1.74、1.30和1.41。V PA、C B Z、P B和P H T谷浓度在有效浓度范围内的比例分别是57.23%、69.02%、22.50%和11.46%，(P<0.05)，两两之间均存在显著性差异；其中毒率分别是8.04%、7.09%、17.50%和16.67%，V PA和C B Z(P=0.584)，P B和P H T(P=0.872)均不存在显著性差异，而V PA和P B(P=0.001)，V PA和P H T(P=0.004)之间均存在显著性差异，C B Z和P B(P=0.001)，V PA和PHT(P=0.003)之间也存在显著性差异。结论：VPA和CBZ监测频率高于PB和PHT，中毒率低于PB和PHT。
目的：總結我院近3年4種抗癲癇藥物的血藥濃度鑑測結果，為臨床安全、閤理應用抗癲癇藥物提供參攷。方法：運用迴顧性研究方法對我院2011年1月～2014年5月共1692例抗癲癇藥物鑑測數據進行分析。結果：丙戊痠鈉(valproate，VPA)、卡馬西平(carbamazepine，CBZ)、苯巴比妥(phenobarbital，PB)和苯妥英鈉(phenytoin，PHT)的鑑測頻率(例/人)分彆為2.46、1.74、1.30和1.41。V PA、C B Z、P B和P H T穀濃度在有效濃度範圍內的比例分彆是57.23%、69.02%、22.50%和11.46%，(P<0.05)，兩兩之間均存在顯著性差異；其中毒率分彆是8.04%、7.09%、17.50%和16.67%，V PA和C B Z(P=0.584)，P B和P H T(P=0.872)均不存在顯著性差異，而V PA和P B(P=0.001)，V PA和P H T(P=0.004)之間均存在顯著性差異，C B Z和P B(P=0.001)，V PA和PHT(P=0.003)之間也存在顯著性差異。結論：VPA和CBZ鑑測頻率高于PB和PHT，中毒率低于PB和PHT。
목적：총결아원근3년4충항전간약물적혈약농도감측결과，위림상안전、합리응용항전간약물제공삼고。방법：운용회고성연구방법대아원2011년1월～2014년5월공1692례항전간약물감측수거진행분석。결과：병무산납(valproate，VPA)、잡마서평(carbamazepine，CBZ)、분파비타(phenobarbital，PB)화분타영납(phenytoin，PHT)적감측빈솔(례/인)분별위2.46、1.74、1.30화1.41。V PA、C B Z、P B화P H T곡농도재유효농도범위내적비례분별시57.23%、69.02%、22.50%화11.46%，(P<0.05)，량량지간균존재현저성차이；기중독솔분별시8.04%、7.09%、17.50%화16.67%，V PA화C B Z(P=0.584)，P B화P H T(P=0.872)균불존재현저성차이，이V PA화P B(P=0.001)，V PA화P H T(P=0.004)지간균존재현저성차이，C B Z화P B(P=0.001)，V PA화PHT(P=0.003)지간야존재현저성차이。결론：VPA화CBZ감측빈솔고우PB화PHT，중독솔저우PB화PHT。
Objective:To summarize the monitoring results on plasma concentration of four kinds of anti-epilepsy drug in the last three years in our hospital,which can provide reference for safety and rational use anti-epilepsy in clinic. Methods:The blood concentration results from 1692 cases of anti-epilepsy drug from January 2011 to May 2014 were analyzed by retrospective methods. Results:Monitoring frequency (cases per each patient) of valproate (VPA), carbamazepine (CBZ), phenobarbital (PB) and phenytoin (PHT) was 2.46、1.74、1.30 and 1.41 in their turns. The percentage of blood concentration within effective range of trough concentration of VPA, CBZ, PB and PHT was 57.23%,69.02%,22.50%,and 11.46%, respectively, What’s more, P value was lower than 0.05 and they had significant difference between each other. Toxicity rate was 8.04%, 7.09%, 17.50%and 16.67%, respectively. VPA and CBZ (P=0.584), both PB and PHT (P=0.872) didn't show significant difference in poisoning rate. While VPA and PB (P=0.001), VPA and PHT (P=0.004) both had significant difference in poisoning rate. CBZ and PB (P=0.001), CBZ and PHT (P=0.003) also showed significant difference in poisoning rate. Conclusion:Monitoring frequency of VPA and CBZ was higher than PB and PHT, while poisoning rate was lower than PB and PHT.
