中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
10期
6-7
,共2页
慢性阻塞性肺疾病%辛伐他汀%大环内酯类药物%抗炎作用
慢性阻塞性肺疾病%辛伐他汀%大環內酯類藥物%抗炎作用
만성조새성폐질병%신벌타정%대배내지류약물%항염작용
Chronic obstructive pulmonary disease%Simvastatin%Macrolides%Inflammatory effects
目的：探讨辛伐他丁联合小剂量大环内酯类药物对慢性阻塞性肺疾病患者的急性发作、肺功能及生活质量的影响。方法将108例慢性阻塞性肺疾病患者随机分成小剂量大环内酯类治疗组（A组）、辛伐他汀治疗组（B组）和小剂量大环内酯类联合辛伐他汀治疗组（C组）。A组给予罗红霉素治疗，B组给予辛伐他汀治疗，C组患者给与罗红霉素联合辛伐他汀治疗。记录三组患者12周内急性发作的人数，并对三组患者治疗前后的呼吸系统症状、SGEQ评分、治疗前后的FEV1%测定的生活质量进行比较。结果 C组12周内急性发作2例，A组急性发作8例；C组急性发作6例。将三组患者治疗之后症状改善方面以及FEV1%、SCRQ评分进行比较，差异有统计学意义（P＜0.05）。结论辛伐他汀联合小剂量大环内酯类药物治疗慢性阻塞性肺疾病能明显改善COPD患者的肺功能、减少急性发作的次数、提高患者的生活质量。
目的：探討辛伐他丁聯閤小劑量大環內酯類藥物對慢性阻塞性肺疾病患者的急性髮作、肺功能及生活質量的影響。方法將108例慢性阻塞性肺疾病患者隨機分成小劑量大環內酯類治療組（A組）、辛伐他汀治療組（B組）和小劑量大環內酯類聯閤辛伐他汀治療組（C組）。A組給予囉紅黴素治療，B組給予辛伐他汀治療，C組患者給與囉紅黴素聯閤辛伐他汀治療。記錄三組患者12週內急性髮作的人數，併對三組患者治療前後的呼吸繫統癥狀、SGEQ評分、治療前後的FEV1%測定的生活質量進行比較。結果 C組12週內急性髮作2例，A組急性髮作8例；C組急性髮作6例。將三組患者治療之後癥狀改善方麵以及FEV1%、SCRQ評分進行比較，差異有統計學意義（P＜0.05）。結論辛伐他汀聯閤小劑量大環內酯類藥物治療慢性阻塞性肺疾病能明顯改善COPD患者的肺功能、減少急性髮作的次數、提高患者的生活質量。
목적：탐토신벌타정연합소제량대배내지류약물대만성조새성폐질병환자적급성발작、폐공능급생활질량적영향。방법장108례만성조새성폐질병환자수궤분성소제량대배내지류치료조（A조）、신벌타정치료조（B조）화소제량대배내지류연합신벌타정치료조（C조）。A조급여라홍매소치료，B조급여신벌타정치료，C조환자급여라홍매소연합신벌타정치료。기록삼조환자12주내급성발작적인수，병대삼조환자치료전후적호흡계통증상、SGEQ평분、치료전후적FEV1%측정적생활질량진행비교。결과 C조12주내급성발작2례，A조급성발작8례；C조급성발작6례。장삼조환자치료지후증상개선방면이급FEV1%、SCRQ평분진행비교，차이유통계학의의（P＜0.05）。결론신벌타정연합소제량대배내지류약물치료만성조새성폐질병능명현개선COPD환자적폐공능、감소급성발작적차수、제고환자적생활질량。
Objective To investigate simvastatin combined with low dose macrolides in chronic obstructive pulmonary disease in patients with acute exacerbation, lung function and quality of life . Methods 108 cases of chronic obstructive pulmonary disease were randomly divided into low-dose macrolide therapy group (A), simvastatin treatment group (B) and low-dose simvastatin macrolide combination therapy group (C group ). A group was given roxithromycin treatment , B group received simvastatin , C group of patients given roxithromycin simvastatin treatment. Record three groups of patients within 12 weeks the number of exacerbations, and three groups of patients before and after treatment of respiratory symptoms , SGEQ score, FEV1%was measured before and after treatment to compare the quality of life . Results C group, 2 cases of acute exacerbation of 12 weeks , A group of eight cases of acute attacks;C group of six cases of acute episodes . The three groups of patients as well as improvement in symptoms after treatment FEV1%, SCRQ scores were compared , the difference was statistically significant (P<0.05). Conclusions Simvastatin combined with low dose macrolide treatment of chronic obstructive pulmonary disease can significantly improve lung function in patients with COPD , reducing the number of exacerbations , improve the patient's quality of life.
