CAJ | 학술논문

目的：观察乌司他丁干预后对重度烧伤患者补体 C3、C4、B 因子影响。对乌司他丁干预后重度烧伤患者补体的影响进行评估，从而指导临床工作。方法61例重度烧伤患者随机分为对照组和乌司他丁治疗组，伤后6 h，治疗后12 h、伤后24、伤后48 h，伤后3 d 抽取空腹静脉血。观察补体 C3、C4、B 因子的变化规律。结果①在伤后12 h，伤后24 h，48 h 干预后补体 C3、C4，B 因子治疗组高于对照组。②伤后72 h 治疗组补体C3、C4，B 因子与治疗组差异无统计学意义。结论乌司他丁干预后可以提高重度烧伤患者补体 C3、C4、B 因子，补体 C3、C4、B 因子也可以更快地恢复。乌司他丁可以提高机体的免疫功能和调节补体介导的炎症反应。
목적：관찰오사타정간예후대중도소상환자보체 C3、C4、B 인자영향。대오사타정간예후중도소상환자보체적영향진행평고，종이지도림상공작。방법61례중도소상환자수궤분위대조조화오사타정치료조，상후6 h，치료후12 h、상후24、상후48 h，상후3 d 추취공복정맥혈。관찰보체 C3、C4、B 인자적변화규률。결과①재상후12 h，상후24 h，48 h 간예후보체 C3、C4，B 인자치료조고우대조조。②상후72 h 치료조보체C3、C4，B 인자여치료조차이무통계학의의。결론오사타정간예후가이제고중도소상환자보체 C3、C4、B 인자，보체 C3、C4、B 인자야가이경쾌지회복。오사타정가이제고궤체적면역공능화조절보체개도적염증반응。
Objective To investigate the change of complement C3,C4 and B factor on severe burn treated with ulinastatin.The effects of ulinastatin on complement are assessed.Methods Sixty-one cases of severe burn patients were randomly divided into control group and ulinastatin treatment group.The venous blood samples were determined 6 hours after injury,12 hours after injury,24 hours after injury,48 hours after injury and 3 days after injury,respectively.The change of complement C3,C4 and B factor were observed.Results ①At 12 hours after injury,24 hours after injury and 48 hours after injury,complement,C3,C4 and B factor of the treatment group was higher than the control group.② There was no statistical difference in the treatment group and the control group.Conclusion Ulinastatin can improve severe burns complement C3,C4,B factor and modulate the inflam-matory response mediated by complement.And it can improve immune function.