国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2012年
11期
862-865
,共4页
卒中%脑缺血%免疫抑制%感染
卒中%腦缺血%免疫抑製%感染
졸중%뇌결혈%면역억제%감염
Stroke%Brain Ischemia%Immunosuppression%Infection
卒中相关性感染是卒中患者死亡的主要原因之一.最近的研究表明,卒中诱导的免疫抑制可使增高患者的感染易感性.卒中后免疫系统呈现双相变化.卒中后中枢神经系统驻留细胞(主要是小胶质细胞)被激活,产生促炎细胞因子和趋化因子,参与缺血性损伤;随后出现的系统性免疫抑制虽可增高患者感染易感性,但也促进神经发生.交感神经系统过度激活是免疫抑制发生的关键.
卒中相關性感染是卒中患者死亡的主要原因之一.最近的研究錶明,卒中誘導的免疫抑製可使增高患者的感染易感性.卒中後免疫繫統呈現雙相變化.卒中後中樞神經繫統駐留細胞(主要是小膠質細胞)被激活,產生促炎細胞因子和趨化因子,參與缺血性損傷;隨後齣現的繫統性免疫抑製雖可增高患者感染易感性,但也促進神經髮生.交感神經繫統過度激活是免疫抑製髮生的關鍵.
졸중상관성감염시졸중환자사망적주요원인지일.최근적연구표명,졸중유도적면역억제가사증고환자적감염역감성.졸중후면역계통정현쌍상변화.졸중후중추신경계통주류세포(주요시소효질세포)피격활,산생촉염세포인자화추화인자,삼여결혈성손상;수후출현적계통성면역억제수가증고환자감염역감성,단야촉진신경발생.교감신경계통과도격활시면역억제발생적관건.
Stroke-associated infection is a leading cause of death in patients with stroke.Recent research indicated that stroke-induced immunodepression increases the susceptibility to infection.The immune system shows a biphasic change after stroke.Tne resident cells (mainly microglia) in the central nervous system are activated following stroke and produce pro-inflammatory cytokines and chemokines,which are involved in ischemic injury.Subsequent systemic immunodepression can result in increases susceptibility to infection,but it also facilitate neurogenesis.The ovcractivity of the sympathetic nervous system is the key to the development of immune suppression.The strategies for controlling stroke-associated infection include sympathetic antagonists,immunomodulators and prophylactic antibiotic therapy.